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The FASEB Journal, Vol 7, 1354-1358, Copyright © 1993 by The Federation of American Societies for Experimental Biology

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Noncholinergic functions of cholinesterases

AS Balasubramanian and CD Bhanumathy
Department of Neurological Sciences, Christian Medical College and Hospital, Vellore, India.

Cholinesterases (acetylcholinesterase and butyrylcholinesterase) exhibit additional catalytic activities apart from their well-known action in hydrolyzing choline esters. An amine-sensitive aryl acylamidase activity is exhibited by both acetyl- and butyrylcholinesterases. A metallocarboxypeptidase-like activity is found associated with both acetyl- and butyrylcholinesterases. The peptidase activity exhibited by butyrylcholinesterase was located in a 50-kDa COOH-terminal fragment. Acetylcholinesterase is implicated in noncholinergic functions in the substantia nigra. A relationship between tumorigenesis, cell differentiation, and cholinesterases has been speculated. The sequence similarities between different esterases, lipases, thyroglobulin, cell adhesion proteins, and cholinesterases would make it appear that cholinesterases are capable of exhibiting more than one biological activity and their functions are wider than what is hitherto known.




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Copyright © 1993 by The Federation of American Societies for Experimental Biology.