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The FASEB Journal, Vol 7, 1233-1241, Copyright © 1993 by The Federation of American Societies for Experimental Biology
REVIEWS |
CB Knudson and W Knudson
Department of Biochemistry, Rush-Presbyterian-St. Luke's Medical Center, Chicago, Illinois 60612.
The high molecular weight glycosaminoglycan hyaluronan plays an important role in tissue remodeling during development, normal tissue homeostasis, and disease. The interaction of hyaluronan with matrix hyaluronan-binding proteins and cell-surface hyaluronan receptors regulates many aspects of cell behavior such as cell migration, cell- cell adhesion, and cell differentiation. Hyaluronan-binding proteins have been grouped together as a family termed hyaladherins--further subdivided in matrix and cell-surface hyaladherins (receptors). Specific hyaluronan-hyaladherin interactions that affect cell behavior are the focus of this review. Both clearance and turnover of hyaluronan involve hyaluronan receptor-mediated endocytosis. Pericellular matrix assembly and retention on many cells, especially chondrocytes, are mediated by hyaluronan receptors, in coordination with other matrix hyaladherins. Hyaluronan can also have an independent, direct effect on cell-to-cell adhesion as well as migration, again mediated by specific cell-surface hyaluronan receptors. This is especially apparent in tumor cells, where metastatic potential is correlated with hyaluronan receptor expression. As migrating cells encounter new environments enriched in matrix hyaladherins, the capacity for matrix assembly may terminate cell migration. Thus, the temporal/spatial deposition of particular matrix hyaladherins also serves as signals or matrix cues to alter cell behavior.
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J. P. Sleeman, K. Kondo, J. Moll, H. Ponta, and P. Herrlich Variant Exons v6 and v7 Together Expand the Repertoire of Glycosaminoglycans Bound by CD44 J. Biol. Chem., December 12, 1997; 272(50): 31837 - 31844. [Abstract] [Full Text] [PDF]
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H. Watanabe, S. C. Cheung, N. Itano, K. Kimata, and Y. Yamada Identification of Hyaluronan-binding Domains of Aggrecan J. Biol. Chem., October 31, 1997; 272(44): 28057 - 28065. [Abstract] [Full Text] [PDF]
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 L. Ye, R. Mora, N. Akhayani, C. C. Haudenschild, and G. Liau Growth Factor and Cytokine-Regulated Hyaluronan-Binding Protein TSG-6 Is Localized to the Injury-Induced Rat Neointima and Confers Enhanced Growth in Vascular Smooth Muscle Cells Circ. Res., September 19, 1997; 81(3): 289 - 296. [Abstract] [Full Text]
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 P. Teder and P. Heldin Mechanism of Impaired Local Hyaluronan Turnover in Bleomycin-induced Lung Injury in Rat Am. J. Respir. Cell Mol. Biol., September 1, 1997; 17(3): 376 - 385. [Abstract] [Full Text]
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W. Lin, S. Shuster, H. I. Maibach, and R. Stern Patterns of Hyaluronan Staining Are Modified by Fixation Techniques J. Histochem. Cytochem., August 1, 1997; 45(8): 1157 - 1164. [Abstract] [Full Text] [PDF]
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A. P. Spicer, J. S. Olson, and J. A. McDonald Molecular Cloning and Characterization of a cDNA Encoding the Third Putative Mammalian Hyaluronan Synthase J. Biol. Chem., April 4, 1997; 272(14): 8957 - 8961. [Abstract] [Full Text] [PDF]
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 M. R. Natowicz, M. P. Short, Y. Wang, G. R. Dickersin, M. C. Gebhardt, D. I. Rosenthal, K. B. Sims, and A. E. Rosenberg Clinical and Biochemical Manifestations of Hyaluronidase Deficiency N. Engl. J. Med., October 3, 1996; 335(14): 1029 - 1033. [Full Text] [PDF]
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V. B. Lokeshwar, N. Iida, and L. Y.W. Bourguignon The Cell Adhesion Molecule, GP116, Is a New CD44 Variant (ex14/v10) Involved in Hyaluronic Acid Binding and Endothelial Cell Proliferation J. Biol. Chem., September 27, 1996; 271(39): 23853 - 23864. [Abstract] [Full Text] [PDF]
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A. P. Spicer, M. L. Augustine, and J. A. McDonald Molecular Cloning and Characterization of a Putative Mouse Hyaluronan Synthase J. Biol. Chem., September 20, 1996; 271(38): 23400 - 23406. [Abstract] [Full Text] [PDF]
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T. B. Deb and K. Datta Molecular Cloning of Human Fibroblast Hyaluronic Acid-binding Protein Confirms Its Identity with P-32, a Protein Co-purified with Splicing Factor SF2 J. Biol. Chem., January 26, 1996; 271(4): 2206 - 2212. [Abstract] [Full Text] [PDF]
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 M Goebeler, D Kaufmann, E. Brocker, and C. Klein Migration of highly aggressive melanoma cells on hyaluronic acid is associated with functional changes, increased turnover and shedding of CD44 receptors J. Cell Sci., January 7, 1996; 109(7): 1957 - 1964. [Abstract] [PDF]
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M. Buschmann, E. Hunziker, Y. Kim, and A. Grodzinsky Altered aggrecan synthesis correlates with cell and nucleus structure in statically compressed cartilage J. Cell Sci., January 2, 1996; 109(2): 499 - 508. [Abstract] [PDF]
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N. Grammatikakis, A. Grammatikakis, M. Yoneda, Q. Yu, S. D. Banerjee, and B. P. Toole A Novel Glycosaminoglycan-binding Protein Is the Vertebrate Homologue of the Cell Cycle Control Protein, Cdc37 J. Biol. Chem., July 7, 1995; 270(27): 16198 - 16205. [Abstract] [Full Text] [PDF]
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E. Nagy and W. F. C. Rigby Glyceraldehyde-3-phosphate Dehydrogenase Selectively Binds AU-rich RNA in the NAD[IMAGE]-binding Region (Rossmann Fold) J. Biol. Chem., February 10, 1995; 270(6): 2755 - 2763. [Abstract] [Full Text] [PDF]
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S. Neame, C. Uff, H Sheikh, S. Wheatley, and C. Isacke CD44 exhibits a cell type dependent interaction with triton X-100 insoluble, lipid rich, plasma membrane domains J. Cell Sci., January 9, 1995; 108(9): 3127 - 3135. [Abstract] [PDF]
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C Wu, A. Chung, and J. McDonald A novel role for alpha 3 beta 1 integrins in extracellular matrix assembly J. Cell Sci., January 6, 1995; 108(6): 2511 - 2523. [Abstract] [PDF]
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M. Buschmann, Y. Gluzband, A. Grodzinsky, and E. Hunziker Mechanical compression modulates matrix biosynthesis in chondrocyte/agarose culture J. Cell Sci., January 4, 1995; 108(4): 1497 - 1508. [Abstract] [PDF]
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A Perschl, J Lesley, N English, R Hyman, and I. Trowbridge Transmembrane domain of CD44 is required for its detergent insolubility in fibroblasts J. Cell Sci., January 3, 1995; 108(3): 1033 - 1041. [Abstract] [PDF]
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C. Isacke The role of the cytoplasmic domain in regulating CD44 function J. Cell Sci., January 9, 1994; 107(9): 2353 - 2359. [PDF]
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L. Zhuo, M. Yoneda, M. Zhao, W. Yingsung, N. Yoshida, Y. Kitagawa, K. Kawamura, T. Suzuki, and K. Kimata Defect in SHAP-Hyaluronan Complex Causes Severe Female Infertility. A STUDY BY INACTIVATION OF THE BIKUNIN GENE IN MICE J. Biol. Chem., March 9, 2001; 276(11): 7693 - 7696. [Abstract] [Full Text] [PDF]
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C. Heldermon, P. L. DeAngelis, and P. H. Weigel Topological Organization of the Hyaluronan Synthase from Streptococcus pyogenes J. Biol. Chem., January 12, 2001; 276(3): 2037 - 2046. [Abstract] [Full Text] [PDF]
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B. Zhou, J. A. Weigel, L. Fauss, and P. H. Weigel Identification of the Hyaluronan Receptor for Endocytosis (HARE) J. Biol. Chem., November 22, 2000; 275(48): 37733 - 37741. [Abstract] [Full Text] [PDF]
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R. Prevo, S. Banerji, D. J. P. Ferguson, S. Clasper, and D. G. Jackson Mouse LYVE-1 Is an Endocytic Receptor for Hyaluronan in Lymphatic Endothelium J. Biol. Chem., May 25, 2001; 276(22): 19420 - 19430. [Abstract] [Full Text] [PDF]
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