FASEB J.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Rose, R. C.
Right arrow Articles by Bode, A. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Rose, R. C.
Right arrow Articles by Bode, A. M.

The FASEB Journal, Vol 7, 1135-1142, Copyright © 1993 by The Federation of American Societies for Experimental Biology

REVIEWS

Biology of free radical scavengers: an evaluation of ascorbate

RC Rose and AM Bode
Department of Physiology and Biophysics, Chicago Medical School, Illinois 60064.

Reactive free radical species (R.) are associated with several forms of tissue damage and disease, and also with the process of aging. Protection is thought to be available in the form of endogenous compounds that react with and thereby "scavenge" the R.. Because many R. are reactive forms of oxygen, an effective scavenger is often referred to as an antioxidant. To be an effective antioxidant physiologically, a substance must have certain chemical and biological properties: it must be present in adequate amounts in the body; it must react with a variety of R.; it must be suitable for compartmentation; it must be readily available; it might be suitable for regeneration; it must be conserved by the kidneys; and it must have tolerable toxicity. Several water-soluble candidates are mentioned, with most having no more than one or two of the attributes listed. Ascorbic acid is discussed in detail, and an analysis is made of whether it has the properties mentioned.


This article has been cited by other articles:


Home page
 Am. J. Clin. Nutr.Home page
A. G. Tan, P. Mitchell, V. M Flood, G. Burlutsky, E. Rochtchina, R. G Cumming, and J. J. Wang
Antioxidant nutrient intake and the long-term incidence of age-related cataract: the Blue Mountains Eye Study
Am. J. Clinical Nutrition, June 1, 2008; 87(6): 1899 - 1905.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
B. Mackenzie, A. C. Illing, and M. A. Hediger
Transport model of the human Na+-coupled L-ascorbic acid (vitamin C) transporter SVCT1
Am J Physiol Cell Physiol, February 1, 2008; 294(2): C451 - C459.
[Abstract] [Full Text] [PDF]

Home page
 Eur J OrthodHome page
H. Bulut, A. D. Kaya, and M. Turkun
Tensile bond strength of brackets after antioxidant treatment on bleached teeth
Eur J Orthod, October 1, 2005; 27(5): 466 - 471.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
J. M. May, Z.-c. Qu, and C. E. Cobb
Human Erythrocyte Recycling of Ascorbic Acid: RELATIVE CONTRIBUTIONS FROM THE ASCORBATE FREE RADICAL AND DEHYDROASCORBIC ACID
J. Biol. Chem., April 9, 2004; 279(15): 14975 - 14982.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
K.-i. Hosoya, A. Minamizono, K. Katayama, T. Terasaki, and M. Tomi
Vitamin C Transport in Oxidized Form across the Rat Blood-Retinal Barrier
Invest. Ophthalmol. Vis. Sci., April 1, 2004; 45(4): 1232 - 1239.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
C. Vergely, F. Goirand, A. Ecarnot-Laubriet, C. Renard, D. Moreau, J.-C. Guilland, M. Dumas, and L. Rochette
Vitamin C Deficiency Exerts Paradoxical Cardiovascular Effects in Osteogenic Disorder Shionogi (ODS) Rats
J. Nutr., April 1, 2004; 134(4): 729 - 735.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
J. M. Roberts, J. L. Balk, L. M. Bodnar, J. M. Belizan, E. Bergel, and A. Martinez
Nutrient Involvement in Preeclampsia
J. Nutr., May 1, 2003; 133(5): 1684S - 1692.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
M. M. Knight, S. R. Roberts, D. A. Lee, and D. L. Bader
Live cell imaging using confocal microscopy induces intracellular calcium transients and cell death
Am J Physiol Cell Physiol, April 1, 2003; 284(4): C1083 - C1089.
[Abstract] [Full Text] [PDF]

Home page
 Pharmacol. Rev.Home page
Y. Gilgun-Sherki, Z. Rosenbaum, E. Melamed, and D. Offen
Antioxidant Therapy in Acute Central Nervous System Injury: Current State
Pharmacol. Rev., June 1, 2002; 54(2): 271 - 284.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
H. Tatemoto, K. Ootaki, K. Shigeta, and N. Muto
Enhancement of Developmental Competence after In Vitro Fertilization of Porcine Oocytes by Treatment with Ascorbic Acid 2-O-{alpha}-Glucoside During In Vitro Maturation
Biol Reprod, December 1, 2001; 65(6): 1800 - 1806.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
J. Huang, D. B. Agus, C. J. Winfree, S. Kiss, W. J. Mack, R. A. McTaggart, T. F. Choudhri, L. J Kim, J Mocco, D. J. Pinsky, et al.
Dehydroascorbic acid, a blood-brain barrier transportable form of vitamin C, mediates potent cerebroprotection in experimental stroke
PNAS, September 25, 2001; 98(20): 11720 - 11724.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
N. Hail Jr., E. M. Youssef, and R. Lotan
Evidence Supporting a Role for Mitochondrial Respiration in Apoptosis Induction by the Synthetic Retinoid CD437
Cancer Res., September 1, 2001; 61(18): 6698 - 6702.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
A. S. Andrew, L. R. Klei, and A. Barchowsky
Nickel requires hypoxia-inducible factor-1{alpha}, not redox signaling, to induce plasminogen activator inhibitor-1
Am J Physiol Lung Cell Mol Physiol, September 1, 2001; 281(3): L607 - L615.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
C. Vergely, C. Perrin, A. Laubriet, A. Oudot, M. Zeller, J.-C. Guilland, and L. Rochette
Postischemic myocardial recovery and oxidative stress status of vitamin C deficient rat hearts
Cardiovasc Res, July 1, 2001; 51(1): 89 - 99.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
P. H. Kodaman and H. R. Behrman
Hormone-Regulated and Glucose-Sensitive Transport of Dehydroascorbic Acid in Immature Rat Granulosa Cells
Endocrinology, August 1, 1999; 140(8): 3659 - 3665.
[Abstract] [Full Text]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
M. P. Merker, L. E. Olson, R. D. Bongard, M. K. Patel, J. H. Linehan, and C. A. Dawson
Ascorbate-mediated transplasma membrane electron transport in pulmonary arterial endothelial cells
Am J Physiol Lung Cell Mol Physiol, May 1, 1998; 274(5): L685 - L693.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
Y. Y.C. Lo, J. M.S. Wong, and T. F. Cruz
Reactive Oxygen Species Mediate Cytokine Activation of c-Jun NH2-terminal Kinases
J. Biol. Chem., June 28, 1996; 271(26): 15703 - 15707.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
K. Kobayashi, S. Tagawa, S. Sano, and K. Asada
A Direct Demonstration of the Catalytic Action of Monodehydroascorbate Reductase by Pulse Radiolysis
J. Biol. Chem., November 17, 1995; 270(46): 27551 - 27554.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
Y. Y. C. Lo and T. F. Cruz
Involvement of Reactive Oxygen Species in Cytokine and Growth Factor Induction of c-fos Expression in Chondrocytes
J. Biol. Chem., May 19, 1995; 270(20): 11727 - 11730.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. M. VanDuijn, K. Tijssen, J. VanSteveninck, P. J. A. Van den Broek, and J. Van der Zee
Erythrocytes Reduce Extracellular Ascorbate Free Radicals Using Intracellular Ascorbate as an Electron Donor
J. Biol. Chem., September 1, 2000; 275(36): 27720 - 27725.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1993 by The Federation of American Societies for Experimental Biology.