FASEB J.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Zambetti, G. P.
Right arrow Articles by Levine, A. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Zambetti, G. P.
Right arrow Articles by Levine, A. J.

The FASEB Journal, Vol 7, 855-865, Copyright © 1993 by The Federation of American Societies for Experimental Biology

REVIEWS

A comparison of the biological activities of wild-type and mutant p53

GP Zambetti and AJ Levine
Department of Molecular Biology, Princeton University, New Jersey 08544.

Tumorigenesis is characterized by a series of genetic alterations in both dominant oncogenes and tumor suppressor genes. A hallmark of tumor suppressor genes is that both alleles are generally altered during transformation, which usually represents a loss of function phenotype. The p53 tumor suppressor gene is the most frequently affected gene detected in human cancer. There is now growing evidence suggesting that mutation of p53 may involve not only a loss of function of wild-type p53 activity but also a gain of function phenotype contributed by the mutant p53 protein. The study of the biological properties and functions of both wild-type and mutant p53 is central to our understanding of human cancer. These properties and functions of wild- type and mutant p53 will be compared and contrasted here and elsewhere within this thematic issue. In addition, the mechanisms of inactivation of p53 function, which include: 1) mutation, 2) inhibition by viral oncogene products, 3) inhibition by cellular regulators, and 4) alteration in subcellular localization, will be discussed.


This article has been cited by other articles:


Home page
 JNMHome page
R. J. Gillies, I. Robey, and R. A. Gatenby
Causes and Consequences of Increased Glucose Metabolism of Cancers
J. Nucl. Med., June 1, 2008; 49(Suppl_2): 24S - 42S.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Epidemiol. Biomarkers Prev.Home page
H. Lind, P. O. Ekstrom, D. Ryberg, V. Skaug, T. Andreassen, L. Stangeland, A. Haugen, and S. Zienolddiny
Frequency of TP53 Mutations in Relation to Arg72Pro Genotypes in Non Small Cell Lung Cancer
Cancer Epidemiol. Biomarkers Prev., October 1, 2007; 16(10): 2077 - 2081.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. GenomicsHome page
R. N. Morrison, G. A. Cooper, B. F. Koop, M. L. Rise, A. R. Bridle, M. B. Adams, and B. F. Nowak
Transcriptome profiling the gills of amoebic gill disease (AGD)-affected Atlantic salmon (Salmo salar L.): a role for tumor suppressor p53 in AGD pathogenesis?
Physiol Genomics, September 14, 2006; 26(1): 15 - 34.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
A. N. West, R. C. Ribeiro, J. Jenkins, C. Rodriguez-Galindo, B. C. Figueiredo, R. Kriwacki, and G. P. Zambetti
Identification of a Novel Germ Line Variant Hotspot Mutant p53-R175L in Pediatric Adrenal Cortical Carcinoma.
Cancer Res., May 15, 2006; 66(10): 5056 - 5062.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
M. J. Scian, K. E. R. Stagliano, M. A. E. Anderson, S. Hassan, M. Bowman, M. F. Miles, S. P. Deb, and S. Deb
Tumor-Derived p53 Mutants Induce NF-{kappa}B2 Gene Expression
Mol. Cell. Biol., November 15, 2005; 25(22): 10097 - 10110.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
T. Choudhuri, S. Pal, T. Das, and G. Sa
Curcumin Selectively Induces Apoptosis in Deregulated Cyclin D1-expressed Cells at G2 Phase of Cell Cycle in a p53-dependent Manner
J. Biol. Chem., May 20, 2005; 280(20): 20059 - 20068.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
G. Mallikarjuna, S. Dhanalakshmi, R. P. Singh, C. Agarwal, and R. Agarwal
Silibinin Protects against Photocarcinogenesis via Modulation of Cell Cycle Regulators, Mitogen-Activated Protein Kinases, and Akt Signaling
Cancer Res., September 1, 2004; 64(17): 6349 - 6356.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
Z. R. A. Razak, R. J. Varkonyi, M. Kulp-McEliece, C. Caslini, J. R. Testa, M. E. Murphy, and D. Broccoli
p53 Differentially Inhibits Cell Growth Depending on the Mechanism of Telomere Maintenance
Mol. Cell. Biol., July 1, 2004; 24(13): 5967 - 5977.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
F. Schwartzenberg-Bar-Yoseph, M. Armoni, and E. Karnieli
The Tumor Suppressor p53 Down-Regulates Glucose Transporters GLUT1 and GLUT4 Gene Expression
Cancer Res., April 1, 2004; 64(7): 2627 - 2633.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
M. Wierdl, C. L. Morton, L. C. Harris, M. K. Danks, J. D. Schuetz, and P. M. Potter
p53-Mediated Regulation of Expression of a Rabbit Liver Carboxylesterase Confers Sensitivity to 7-Ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin (CPT-11)
J. Pharmacol. Exp. Ther., February 1, 2003; 304(2): 699 - 705.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Pharmacol.Home page
A. A. Joshi, Z. Wu, R. F. Reed, and D. P. Suttle
Nuclear Factor-Y Binding to the Topoisomerase IIalpha Promoter Is Inhibited by Both the p53 Tumor Suppressor and Anticancer Drugs
Mol. Pharmacol., February 1, 2003; 63(2): 359 - 367.
[Abstract] [Full Text] [PDF]

Home page
 Molecular Cancer TherapeuticsHome page
P. P. McKenzie, C. R. McPake, A. A. Ashford, E. F. Vanin, and L. C. Harris
MDM2 Does Not Influence p53-mediated Sensitivity to DNA-damaging Drugs
Mol. Cancer Ther., October 1, 2002; 1(12): 1097 - 1104.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
J. Sampath, D. Sun, V. J. Kidd, J. Grenet, A. Gandhi, L. H. Shapiro, Q. Wang, G. P. Zambetti, and J. D. Schuetz
Mutant p53 Cooperates with ETS and Selectively Up-regulates Human MDR1 Not MRP1
J. Biol. Chem., October 12, 2001; 276(42): 39359 - 39367.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
L. Bai and J. L. Merchant
ZBP-89 Promotes Growth Arrest through Stabilization of p53
Mol. Cell. Biol., July 15, 2001; 21(14): 4670 - 4683.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
F. Seiler, B. Rehn, S. Rehn, M. Hermann, and J. Bruch
Quartz Exposure of the Rat Lung Leads to a Linear Dose Response in Inflammation but Not in Oxidative DNA Damage and Mutagenicity
Am. J. Respir. Cell Mol. Biol., April 1, 2001; 24(4): 492 - 498.
[Abstract] [Full Text]

Home page
 CarcinogenesisHome page
J. E. French, G. D. Lacks, C. Trempus, J. K. Dunnick, J. Foley, J. Mahler, R. R. Tice, and R. W. Tennant
Loss of heterozygosity frequency at the Trp53 locus in p53-deficient (+/-) mouse tumors is carcinogen-and tissue-dependent
Carcinogenesis, January 1, 2001; 22(1): 99 - 106.
[Abstract] [Full Text] [PDF]

Home page
 Cell Growth Differ.Home page
S. V. Gaitonde, W. Qi, R. R. Falsey, N. Sidell, and J. D. Martinez
Morphologic Conversion of a Neuroblastoma-derived Cell Line by E6-mediated p53 Degradation
Cell Growth Differ., January 1, 2001; 12(1): 19 - 27.
[Abstract] [Full Text]

Home page
 CarcinogenesisHome page
J. L. Torino, M. S. Burger, C. A. Reznikoff, and S. Swaminathan
Role of TP53 in repair of N-(deoxyguanosin-8-yl)-4-aminobiphenyl adducts in human transitional cell carcinoma of the urinary bladder
Carcinogenesis, January 1, 2001; 22(1): 147 - 154.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
Y.-P. Lu, Y.-R. Lou, X. H. Li, J. G. Xie, D. Brash, M.-T. Huang, and A. H. Conney
Stimulatory Effect of Oral Administration of Green Tea or Caffeine on Ultraviolet Light-induced Increases in Epidermal Wild-Type p53, p21(WAF1/CIP1), and Apoptotic Sunburn Cells in SKH-1 Mice
Cancer Res., September 1, 2000; 60(17): 4785 - 4791.
[Abstract] [Full Text]

Home page
 Proc. Natl. Acad. Sci. USAHome page
P. J. Moos, K. Edes, and F. A. Fitzpatrick
Inactivation of wild-type p53 tumor suppressor by electrophilic prostaglandins
PNAS, July 19, 2000; (2000) 160241897.
[Abstract] [Full Text]

Home page
 Cancer Epidemiol. Biomarkers Prev.Home page
Y.-H. Shiao, D. Palli, N. E. Caporaso, W. G. Alvord, A. Amorosi, G. Nesi, C. Saieva, G. Masala, J. F. Fraumeni Jr., and J. M. Rice
Genetic and Immunohistochemical Analyses of p53 Independently Predict Regional Metastasis of Gastric Cancers
Cancer Epidemiol. Biomarkers Prev., June 1, 2000; 9(6): 631 - 633.
[Abstract] [Full Text]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
A. Mishra, N. A. Doyle, and W. J. Martin II
Bleomycin-Mediated Pulmonary Toxicity . Evidence for a p53-Mediated Response
Am. J. Respir. Cell Mol. Biol., May 1, 2000; 22(5): 543 - 549.
[Abstract] [Full Text]

Home page
 Cancer Res.Home page
R. Sanchez-Prieto, J. M. Rojas, Y. Taya, and J. S. Gutkind
A Role for the p38 Mitogen-activated Protein Kinase Pathway in the Transcriptional Activation of p53 on Genotoxic Stress by Chemotherapeutic Agents
Cancer Res., May 1, 2000; 60(9): 2464 - 2472.
[Abstract] [Full Text]

Home page
 Am. J. Respir. Crit. Care Med.Home page
W. N. ROM, J. G. HAY, T. C. LEE, Y. JIANG, and K.-M. TCHOU-WONG
Molecular and Genetic Aspects of Lung Cancer
Am. J. Respir. Crit. Care Med., April 1, 2000; 161(4): 1355 - 1367.
[Full Text]

Home page
 Cancer Res.Home page
D. L. Cheo, L. B. Meira, D. K. Burns, A. M. Reis, T. Issac, and E. C. Friedberg
Ultraviolet B Radiation-induced Skin Cancer in Mice Defective in the Xpc, Trp53, and Apex (HAP1) Genes: Genotype-specific Effects on Cancer Predisposition and Pathology of Tumors
Cancer Res., March 1, 2000; 60(6): 1580 - 1584.
[Abstract] [Full Text]

Home page
 Cancer Res.Home page
X. Liu, E. A. Peralta, J. D. I. Ellenhorn, and D. J. Diamond
Targeting of Human p53-overexpressing Tumor Cells by an HLA A*0201-restricted Murine T-Cell Receptor Expressed in Jurkat T Cells
Cancer Res., February 1, 2000; 60(3): 693 - 701.
[Abstract] [Full Text]

Home page
 CarcinogenesisHome page
A.-C. Souici, J. Mirkovitch, P. Hausel, L. K.Keefer, and E. Felley-Bosco
Transition mutation in codon 248 of the p53 tumor suppressor gene induced by reactive oxygen species and a nitric oxide-releasing compound
Carcinogenesis, February 1, 2000; 21(2): 281 - 287.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
G. D. Niswender, J. L. Juengel, P. J. Silva, M. K. Rollyson, and E. W. McIntush
Mechanisms Controlling the Function and Life Span of the Corpus Luteum
Physiol Rev, January 1, 2000; 80(1): 1 - 29.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
P. P. McKenzie, S. M. Guichard, D. S. Middlemas, R. A. Ashmun, M. K. Danks, and L. C. Harris
Wild-Type p53 Can Induce p21 and Apoptosis in Neuroblastoma Cells But the DNA Damage-induced G1 Checkpoint Function
Clin. Cancer Res., December 1, 1999; 5(12): 4199 - 4207.
[Abstract] [Full Text] [PDF]

Home page
 Cell Growth Differ.Home page
M. Athanassiou, Y. Hu, L. Jing, B. Houle, H. Zarbl, and A. M. Mikheev
Stabilization and Reactivation of the p53 Tumor Suppressor Protein in Nontumorigenic Revertants of HeLa Cervical Cancer Cells
Cell Growth Differ., November 1, 1999; 10(11): 729 - 737.
[Abstract] [Full Text]

Home page
 Cancer Res.Home page
Y.-P. Lu, Y.-R. Lou, P. Yen, D. Mitchell, M.-T. Huang, and A. H. Conney
Time Course for Early Adaptive Responses to Ultraviolet B Light in the Epidermis of SKH-1 Mice
Cancer Res., September 1, 1999; 59(18): 4591 - 4602.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
C. Gobert, A. Skladanowski, and A. K. Larsen
The interaction between p53 and DNA topoisomerase I is regulated differently in cells with wild-type and mutant p53
PNAS, August 31, 1999; 96(18): 10355 - 10360.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
Y.-C. Lee, Y.-L. Chang, S.-P. Luh, J.-M. Lee, and J.-S. Chen
Significance of P53 and Rb protein expression in surgically treated non-small cell lung cancers
Ann. Thorac. Surg., August 1, 1999; 68(2): 343 - 347.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
S. T. Shi, G.-Y. Yang, L.-D. Wang, Z. Xue, B. Feng, W. Ding, E. P. Xing, and C. S. Yang
Role of p53 gene mutations in human esophageal carcinogenesis: results from immunohistochemical and mutation analyses of carcinomas and nearby non-cancerous lesions
Carcinogenesis, April 1, 1999; 20(4): 591 - 597.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
F. D. Goodrum and D. A. Ornelles
p53 Status Does Not Determine Outcome of E1B 55-Kilodalton Mutant Adenovirus Lytic Infection
J. Virol., December 1, 1998; 72(12): 9479 - 9490.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
V. G. Gorgoulis, P. Zacharatos, A. Kotsinas, T. Liloglou, A. Kyroudi, M. Veslemes, A. Rassidakis, T. D. Halazonetis, J. K. Field, and C. Kittas
Alterations of the p16-pRb Pathway and the Chromosome Locus 9p21–22 in Non-Small-Cell Lung Carcinomas : Relationship with p53 and MDM2 Protein Expression
Am. J. Pathol., December 1, 1998; 153(6): 1749 - 1765.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
F. W. Quelle, J. Wang, J. Feng, D. Wang, J. L. Cleveland, J. N. Ihle, and G. P. Zambetti
Cytokine rescue of p53-dependent apoptosis and cell cycle arrest is mediated by distinct Jak kinase signaling pathways
Genes & Dev., April 15, 1998; 12(8): 1099 - 1107.
[Abstract] [Full Text]

Home page
 Proc. Natl. Acad. Sci. USAHome page
J. V. Thottassery, G. P. Zambetti, K. Arimori, E. G. Schuetz, and J. D. Schuetz
p53-dependent regulation of MDR1 gene expression causes selective resistance to chemotherapeutic agents
PNAS, September 30, 1997; 94(20): 11037 - 11042.
[Abstract] [Full Text] [PDF]

Home page
 J. Exp. Med.Home page
M. P.M. Vierboom, H. W. Nijman, R. Offringa, E. I.H. v. d. Voort, T. v. Hall, L. v. d. Broek, G. J. Fleuren, P. Kenemans, W. M. Kast, and C. J.M. Melief
Tumor Eradication by Wild-type p53-specific Cytotoxic T Lymphocytes
J. Exp. Med., August 29, 1997; 186(5): 695 - 704.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
X.L Wang, J Wang, and D.E.L Wilcken
Interactive effect of the p53 gene and cigarette smoking on coronary artery disease
Cardiovasc Res, August 1, 1997; 35(2): 250 - 255.
[Abstract] [Full Text] [PDF]

Home page
 INT J SURG PATHOLHome page
P. Robbins
p53 and Breast Cancer
International Journal of Surgical Pathology, October 1, 1996; 4(2): 93 - 110.
[Abstract] [PDF]

Home page
 Genes Dev.Home page
T Bowman, H Symonds, L Gu, C Yin, M Oren, and T Van Dyke
Tissue-specific inactivation of p53 tumor suppression in the mouse.
Genes & Dev., April 1, 1996; 10(7): 826 - 835.
[Abstract] [PDF]

Home page
 J. Biol. Chem.Home page
I. Takenaka, F. Morin, B. R. Seizinger, and N. Kley
Regulation of the Sequence-specific DNA Binding Function of p53 by Protein Kinase C and Protein Phosphatases
J. Biol. Chem., March 10, 1995; 270(10): 5405 - 5411.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. E. Goldsmith, J. M. Gudas, E. Schneider, and K. H. Cowan
Wild Type p53 Stimulates Expression from the Human Multidrug Resistance Promoter in a p53-negative Cell Line
J. Biol. Chem., January 27, 1995; 270(4): 1894 - 1898.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
A J Wagner, J M Kokontis, and N Hay
Myc-mediated apoptosis requires wild-type p53 in a manner independent of cell cycle arrest and the ability of p53 to induce p21waf1/cip1.
Genes & Dev., December 1, 1994; 8(23): 2817 - 2830.
[Abstract] [PDF]

Home page
 ScienceHome page
K. Dameron, O. Volpert, M. Tainsky, and N Bouck
Control of angiogenesis in fibroblasts by p53 regulation of thrombospondin-1
Science, September 9, 1994; 265(5178): 1582 - 1584.
[Abstract] [PDF]

Home page
 Genes Dev.Home page
Y Barak, E Gottlieb, T Juven-Gershon, and M Oren
Regulation of mdm2 expression by p53: alternative promoters produce transcripts with nonidentical translation potential.
Genes & Dev., August 1, 1994; 8(15): 1739 - 1749.
[Abstract] [PDF]

Home page
 J. Cell Sci.Home page
D. A. Jackson, A. B. Hassan, R. J. Errington, and P. R. Cook
Sites in human nuclei where damage induced by ultraviolet light is repaired: localization relative to transcription sites and concentrations of proliferating cell nuclear antigen and the tumour suppressor protein, p53
J. Cell Sci., July 1, 1994; 107(7): 1753 - 1760.
[Abstract] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
P. J. Moos, K. Edes, and F. A. Fitzpatrick
Inactivation of wild-type p53 tumor suppressor by electrophilic prostaglandins
PNAS, August 1, 2000; 97(16): 9215 - 9220.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1993 by The Federation of American Societies for Experimental Biology.