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The FASEB Journal, Vol 7, 87-89, Copyright © 1993 by The Federation of American Societies for Experimental Biology

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tRNA-rRNA interactions and peptidyl transferase

HF Noller
Sinsheimer Laboratories, University of California, Santa Cruz 95064.

The extent to which ribosomal RNA is directly involved in the function of ribosomes has important implications for both the mechanism of translation and the molecular origins of life. Detailed evidence has accumulated that places the anticodon and acceptor ends of tRNA in close proximity to conserved features of rRNA in the ribosome. Recent studies are providing evidence that these features are important for ribosomal function.


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R. Sweeney and M.-C. Yao
An Intragenic Suppressor of Cold Sensitivity Identifies Potentially Interacting Bases in the Peptidyl Transferase Center of Tetrahymena rRNA
Genetics, June 1, 1998; 149(2): 937 - 946.
[Abstract] [Full Text]


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Copyright © 1993 by The Federation of American Societies for Experimental Biology.