FASEB J.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Zipori, D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Zipori, D.

The FASEB Journal, Vol 6, 2691-2697, Copyright © 1992 by The Federation of American Societies for Experimental Biology

REVIEWS

The renewal and differentiation of hemopoietic stem cells

D Zipori
Department of Cell Biology, Weizmann Institute of Science, Rehovot, Israel.

Blood-forming tissues are organized in well-defined microenvironments composed of hemopoietic cells and a supportive stroma of connective tissue and endothelium. Hemopoietic cells segregate to various lineages, all derived from a small population of pluripotent stem cells residing in the bone marrow. Regulation of growth and differentiation, particularly under conditions of perturbations, damage, and disease, is mediated by inducer colony-stimulating factors and interleukins counteracted by inhibitory cytokines. Whereas much is known about the mode of induction of differentiation, insufficient information is available to explain the process of stem cell renewal that is crucial for the longevity of the hemopoietic system. It is also only partially known how inhibition of hemopoietic processes occurs, and what molecules in blood-forming tissues signal organization into discrete patterns. This paper reviews recent progress that has opened new avenues to a better understanding of this highly complex issue.


This article has been cited by other articles:


Home page
 BloodHome page
M. Pevsner-Fischer, V. Morad, M. Cohen-Sfady, L. Rousso-Noori, A. Zanin-Zhorov, S. Cohen, I. R. Cohen, and D. Zipori
Toll-like receptors and their ligands control mesenchymal stem cell functions
Blood, February 15, 2007; 109(4): 1422 - 1432.
[Abstract] [Full Text] [PDF]

Home page
 Stem CellsHome page
D. Zipori
The Stem State: Plasticity Is Essential, Whereas Self-Renewal and Hierarchy Are Optional
Stem Cells, June 1, 2005; 23(6): 719 - 726.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
C. S. McCauslin, J. Wine, L. Cheng, K. D. Klarmann, F. Candotti, P. A. Clausen, S. E. Spence, and J. R. Keller
In vivo retroviral gene transfer by direct intrafemoral injection results in correction of the SCID phenotype in Jak3 knock-out animals
Blood, August 1, 2003; 102(3): 843 - 848.
[Abstract] [Full Text] [PDF]

Home page
 Stem CellsHome page
Y. Shav-Tal and D. Zipori
The Role of Activin A in Regulation of Hemopoiesis
Stem Cells, November 1, 2002; 20(6): 493 - 500.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
D. Zipori and M. Barda-Saad
Role of activin A in negative regulation of normal and tumor B lymphocytes
J. Leukoc. Biol., June 1, 2001; 69(6): 867 - 873.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
N. Brosh, D. Sternberg, J. Honigwachs-Sha'anani, B.-C. Lee, Y. Shav-Tal, E. Tzehoval, L. M. Shulman, J. Toledo, Y. Hacham, P. Carmi, et al.
The Plasmacytoma Growth Inhibitor Restrictin-P Is an Antagonist of Interleukin 6 and Interleukin 11
J. Biol. Chem., December 8, 1995; 270(49): 29594 - 29600.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1992 by The Federation of American Societies for Experimental Biology.