The FASEB Journal, Vol 6, 2660-2666, Copyright © 1992 by The Federation of American Societies for Experimental Biology

REVIEWS

ATP-dependent bacterial transporters and cystic fibrosis: analogy between channels and transporters

GF Ames and H Lecar
Department of Molecular Biology, University of California, Berkeley 94720.

The traffic ATPases superfamily includes known transporters, both prokaryotic and eukaryotic, including the medically important proteins, P-glycoprotein, and the cystic fibrosis gene product (CFTR), which is known to be a Cl- channel. The structure and mechanism of action of the best-studied members of the superfamily, the periplasmic permeases, are described and related to that of CFTR and eukaryotic traffic ATPases in general. The contention is put forward that the distinction between the architecture and mechanisms of action of channels and transporters is blurred.

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