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The FASEB Journal, Vol 6, 2600-2607, Copyright © 1992 by The Federation of American Societies for Experimental Biology

RESEARCH COMMUNICATIONS

Dietary fatty acid thresholds and cholesterolemia

KC Hayes and P Khosla
Foster Biomedical Research Laboratory, Brandeis University, Waltham, Massachusetts 02254.

Results obtained with cebus monkeys indicate that dietary myristic (14:0) and palmitic (16:0) acids exert disparate effects on cholesterol metabolism, whereas the ability of linoleic acid (18:2) to decrease total plasma cholesterol displays an upper limit or threshold. Reanalysis of published data suggests a similar situation pertains in humans. In agreement with an earlier human study, 14:0 appears to be the principal saturated fatty acid that raises plasma cholesterol whereas 18:2 lowers it. Oleic acid (18:1) appears neutral. The effect of 16:0 may vary. In normocholesterolemic subjects consuming diets containing less than or equal to 300 mg/day of cholesterol, 16:0 appears to be without effect on plasma cholesterol. However, in hypercholesterolemic subjects (greater than 225 mg/dl) and especially those consuming diets providing cholesterol intakes of greater than or equal to 400 mg/day, dietary 16:0 may expand the plasma cholesterol pool.


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Copyright © 1992 by The Federation of American Societies for Experimental Biology.