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The FASEB Journal, Vol 6, 2581-2590, Copyright © 1992 by The Federation of American Societies for Experimental Biology
REVIEWS |
M Karin
Department of Pharmacology, School of Medicine, University of California San Diego, La Jolla 92093.
Recent studies indicate that extracellular signals affect cell proliferation and differentiation by modulating transcription factor activity via protein phosphorylation cascades. This review discusses the basic outline of the eukaryotic signal transduction systems used to transmit information from the cell surface to the transcriptional machinery in the nucleus. Several examples that illustrate how these pathways control cell proliferation, differentiation and development are discussed.
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