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The FASEB Journal, Vol 6, 2450-2455, Copyright © 1992 by The Federation of American Societies for Experimental Biology

REVIEWS

Apoptosis: a different type of cell death

LE Gerschenson and RJ Rotello
Department of Pathology, School of Medicine, University of Colorado Health Sciences Center, Denver 80262.

Apoptosis is a type of cell death that plays an important role in early development and growth of normal adult tissues. It is regulated by physiological stimuli and is present in many species and tissues. The main morphological characteristics are nuclear fragmentation and cellular breakdown in apoptotic vesicles. Internucleosomal DNA fragmentation is an important biochemical feature that is the result of a yet to be isolated endonuclease activity. Experiments using RNA and protein synthesis inhibitors suggest the presence of either intracellular repressors or inducers of apoptosis.


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Copyright © 1992 by The Federation of American Societies for Experimental Biology.