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The FASEB Journal, Vol 6, 731-736, Copyright © 1992 by The Federation of American Societies for Experimental Biology
REVIEWS |
JH Capdevila, JR Falck and RW Estabrook
Department of Medicine, Vanderbilt University, Nashville, Tennessee 37232.
Arachidonic acid and many products of the arachidonate cascade serve as substrates for cytochrome P450-mediated metabolism via allylic oxidation, omega hydroxylation, and epoxygenation as well as peroxide rearrangement. Defining the physiological importance of these metabolites is an area of intense research interest. Cytochrome P450- catalyzed reactions play prominent roles in multiplying the structural and functional diversity of the arachidonate metabolic cascade.
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