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The FASEB Journal, Vol 6, 3051-3064, Copyright © 1992 by The Federation of American Societies for Experimental Biology

REVIEWS

Nitric oxide as a secretory product of mammalian cells

C Nathan
Beatrice and Samuel A. Seaver Laboratory, Cornell University Medical College, New York, New York 10021.

Evolution has resorted to nitric oxide (NO), a tiny, reactive radical gas, to mediate both servoregulatory and cytotoxic functions. This article reviews how different forms of nitric oxide synthase help confer specificity and diversity on the effects of this remarkable signaling molecule.


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