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The FASEB Journal, Vol 6, 2820-2825, Copyright © 1992 by The Federation of American Societies for Experimental Biology

RESEARCH COMMUNICATIONS

The Tiresias complex: Huntington's disease as a paradigm of testing for late-onset disorders

NS Wexler
Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, New York 10032.

Huntington's disease represents the first disorder for which positional cloning techniques successfully localized an autosomal gene--in 1983. Events since that time have proved the gene recalcitrant to identification and characterization. Since 1986, presymptomatic and prenatal testing for Huntington's disease has been available internationally, although on a limited basis. Testing for Huntington's disease provides an excellent model for designing service programs for genetic testing for late-onset, fatal disorders, particularly when the gene is not yet in hand and no therapeutic intervention is possible. Special training and precautions must be in place before presymptomatic genetic testing should be offered.


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Copyright © 1992 by The Federation of American Societies for Experimental Biology.