| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
The FASEB Journal, Vol 5, 2068-2077, Copyright © 1991 by The Federation of American Societies for Experimental Biology
REVIEWS |
EA Dennis, SG Rhee, MM Billah and YA Hannun
Department of Chemistry, University of California, San Diego, La Jolla 92093.
Many lipids or lipid-derived products generated by phospholipases acting on phospholipids in membranes are implicated as mediators and second messengers in signal transduction. Our current understanding of the primary sequence relationships within the class of extracellular phospholipase A2's and among the numerous forms of the mammalian phosphatidylinositol-specific phospholipase C's is reviewed. New results suggesting roles for these phospholipases as well as other phospholipases such as phospholipase C and D acting on phosphatidlycholine in generating arachidonic acid for eicosanoid biosynthesis, inositol phosphates for Ca2+ mobilization, and diglyceride for protein kinase C activation through receptor-mediated processes, are discussed. In addition, the possible role of phospholipases acting on sphingolipids such as sphinglomyelinase in generating lipid mediators is considered.
This article has been cited by other articles:
|
|
 |
|
  S. J. Liu Inhibition of L-type Ca2+ channel current and negative inotropy induced by arachidonic acid in adult rat ventricular myocytes Am J Physiol Cell Physiol, November 1, 2007; 293(5): C1594 - C1604. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. Cao, L. Cheng, J. Behar, P. Biancani, and K. M. Harnett IL-1beta signaling in cat lower esophageal sphincter circular muscle Am J Physiol Gastrointest Liver Physiol, October 1, 2006; 291(4): G672 - G680. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. R. Sheppard, M. R. Kelher, E. E. Moore, N. J. D. McLaughlin, A. Banerjee, and C. C. Silliman Structural organization of the neutrophil NADPH oxidase: phosphorylation and translocation during priming and activation J. Leukoc. Biol., November 1, 2005; 78(5): 1025 - 1042. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. M. Harnett, W. Cao, and P. Biancani Signal-Transduction Pathways that Regulate Smooth Muscle Function I. Signal transduction in phasic (esophageal) and tonic (gastroesophageal sphincter) smooth muscles Am J Physiol Gastrointest Liver Physiol, March 1, 2005; 288(3): G407 - G416. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. A. Babcock, T. Dekoj, and N. J. Espat Experimental Studies Defining {omega}-3 Fatty Acid Antiinflammatory Mechanisms and Abrogation of Tumor-Related Syndromes Nutr Clin Pract, February 1, 2005; 20(1): 62 - 74. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. A. Riske and H.-G. Dobereiner Diacylglycerol-Rich Domain Formation in Giant Stearoyl-Oleoyl Phosphatidylcholine Vesicles Driven by Phospholipase C Activity Biophys. J., October 1, 2003; 85(4): 2351 - 2362. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Chahdi, W. S. Choi, Y. M. Kim, and M. A. Beaven Mastoparan Selectively Activates Phospholipase D2 in Cell Membranes J. Biol. Chem., March 28, 2003; 278(14): 12039 - 12045. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Zhao and P. K. J. Kinnunen Modulation of the Activity of Secretory Phospholipase A2 by Antimicrobial Peptides Antimicrob. Agents Chemother., March 1, 2003; 47(3): 965 - 971. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Gebremedhin, K. Yamaura, C. Zhang, J. Bylund, R. C. Koehler, and D. R. Harder Metabotropic Glutamate Receptor Activation Enhances the Activities of Two Types of Ca2+-Activated K+ Channels in Rat Hippocampal Astrocytes J. Neurosci., March 1, 2003; 23(5): 1678 - 1687. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. R. Kozak, B. C. Crews, J. D. Morrow, L.-H. Wang, Y. H. Ma, R. Weinander, P.-J. Jakobsson, and L. J. Marnett Metabolism of the Endocannabinoids, 2-Arachidonylglycerol and Anandamide, into Prostaglandin, Thromboxane, and Prostacyclin Glycerol Esters and Ethanolamides J. Biol. Chem., November 15, 2002; 277(47): 44877 - 44885. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. C. Silliman, E. E. Moore, G. Zallen, R. Gonzalez, J. L. Johnson, D. J. Elzi, X. Meng, K. Hanasaki, J. Ishizaki, H. Arita, et al. Presence of the M-type sPLA2 receptor on neutrophils and its role in elastase release and adhesion Am J Physiol Cell Physiol, October 1, 2002; 283(4): C1102 - C1113. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Pawliczak, C. Han, X.-L. Huang, A. J. Demetris, J. H. Shelhamer, and T. Wu 85-kDa Cytosolic Phospholipase A2 Mediates Peroxisome Proliferator-activated Receptor gamma Activation in Human Lung Epithelial Cells J. Biol. Chem., August 30, 2002; 277(36): 33153 - 33163. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Cao, K. M. Harnett, J. Behar, and P. Biancani PGF2alpha -induced contraction of cat esophageal and lower esophageal sphincter circular smooth muscle Am J Physiol Gastrointest Liver Physiol, August 1, 2002; 283(2): G282 - G291. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. S. Choi, Y. M. Kim, C. Combs, M. A. Frohman, and M. A. Beaven Phospholipases D1 and D2 Regulate Different Phases of Exocytosis in Mast Cells J. Immunol., June 1, 2002; 168(11): 5682 - 5689. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Han, A. J. Demetris, G. Michalopoulos, J. H. Shelhamer, and T. Wu 85-kDa cPLA2 plays a critical role in PPAR-mediated gene transcription in human hepatoma cells Am J Physiol Gastrointest Liver Physiol, April 1, 2002; 282(4): G586 - G597. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. W. Fisher and J. Brookins Adenosine A2A and A2B receptor activation of erythropoietin production Am J Physiol Renal Physiol, November 1, 2001; 281(5): F826 - F832. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. P. Li, T.-M. Chang, D. Wagner, and W. Y. Chey Pancreatic phospholipase A2 from the small intestine is a secretin-releasing factor in rats Am J Physiol Gastrointest Liver Physiol, August 1, 2001; 281(2): G526 - G532. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. J. Jiang, G. M. Hatch, D. Mymin, T. Dembinski, E. A. Kroeger, and P. C. Choy Modulation of cytosolic phospholipase A2 by PPAR activators in human preadipocytes J. Lipid Res., May 1, 2001; 42(5): 716 - 724. [Abstract] [Full Text]
|
|
|
|
|
|
W. Cao, Q. Chen, U. D. Sohn, N. Kim, M. T. Kirber, K. M. Harnett, J. Behar, and P. Biancani Ca2+-induced contraction of cat esophageal circular smooth muscle cells Am J Physiol Cell Physiol, April 1, 2001; 280(4): C980 - C992. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Q. He and M. C. LaPointe Src and Rac Mediate Endothelin-1 and Lysophosphatidic Acid Stimulation of the Human Brain Natriuretic Peptide Promoter Hypertension, February 1, 2001; 37(2): 478 - 484. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Ogura, S. Matsuda, M. Ito, R. Niimi, M. Sumitomo, and Y. Kawarada Chemoprevention of biliary carcinogenesis in Syrian hamsters by the novel carboxamide derivative IS-741 after initiation with N-nitrosobis(2-oxopropyl)amine (BOP) Carcinogenesis, August 1, 2000; 21(8): 1469 - 1475. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Jeyaseelan, A. Armugam, M. Donghui, and N.-H. Tan Structure and Phylogeny of the Venom Group I Phospholipase A2 Gene Mol. Biol. Evol., July 1, 2000; 17(7): 1010 - 1021. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. M. Jung and D. K. Kim Purification and Characterization of a Membrane-Associated 48-Kilodalton Phospholipase A2 in Leaves of Broad Bean Plant Physiology, July 1, 2000; 123(3): 1057 - 1068. [Abstract] [Full Text]
|
|
|
|
 |
|
 M. A. Ghannoum Potential Role of Phospholipases in Virulence and Fungal Pathogenesis Clin. Microbiol. Rev., January 1, 2000; 13(1): 122 - 143. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Chahdi, P. F. Fraundorfer, and M. A. Beaven Compound 48/80 Activates Mast Cell Phospholipase D via Heterotrimeric GTP-Binding Proteins J. Pharmacol. Exp. Ther., January 1, 2000; 292(1): 122 - 130. [Abstract] [Full Text]
|
|
|
|
 |
|
 P. K. Tithof, J. Olivero, K. Ruehle, and P. E. Ganey Activation of Neutrophil Calcium-Dependent and -Independent Phospholipases A2 by Organochlorine Compounds Toxicol. Sci., January 1, 2000; 53(1): 40 - 47. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. B. Cao, K. M. Harnett, Q. Chen, M. K. Jain, J. Behar, and P. Biancani Group I secreted PLA2 and arachidonic acid metabolites in the maintenance of cat LES tone Am J Physiol Gastrointest Liver Physiol, September 1, 1999; 277(3): G585 - G598. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. W. Erickson, P. Langel-Peveri, A. E. Traynor-Kaplan, P. G. Heyworth, and J. T. Curnutte Activation of Human Neutrophil NADPH Oxidase by Phosphatidic Acid or Diacylglycerol in a Cell-free System. ACTIVITY OF DIACYLGLYCEROL IS DEPENDENT ON ITS CONVERSION TO PHOSPHATIDIC ACID J. Biol. Chem., August 6, 1999; 274(32): 22243 - 22250. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X.-L. Yao, M. J. Cowan, M. T. Gladwin, M. M. Lawrence, C. W. Angus, and J. H. Shelhamer Dexamethasone Alters Arachidonate Release from Human Epithelial Cells by Induction of p11 Protein Synthesis and Inhibition of Phospholipase A2 Activity J. Biol. Chem., June 11, 1999; 274(24): 17202 - 17208. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Maggio Modulation of phospholipase A2 by electrostatic fields and dipole potential of glycosphingolipids in monolayers J. Lipid Res., May 1, 1999; 40(5): 930 - 939. [Abstract] [Full Text]
|
|
|
|
 |
|
 J. M. Drazen, E. Israel, and P. M. O'Byrne Treatment of Asthma with Drugs Modifying the Leukotriene Pathway N. Engl. J. Med., January 21, 1999; 340(3): 197 - 206. [Full Text] [PDF]
|
|
|
|
|
|
P. Yu, Q. Chen, Z. Xiao, K. Harnett, P. Biancani, and J. Behar Signal transduction pathways mediating CCK-induced gallbladder muscle contraction Am J Physiol Gastrointest Liver Physiol, August 1, 1998; 275(2): G203 - G211. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Sbrissa, A. Hajra, and K. N. Bitar Origin of molecular species of diacylglycerol induced by bombesin in smooth muscle cells from rabbit rectosigmoid Am J Physiol Gastrointest Liver Physiol, July 1, 1998; 275(1): G138 - G150. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. S. Cissel, P. F. Fraundorfer, and M. A. Beaven Thapsigargin-Induced Secretion Is Dependent on Activation of a Cholera Toxin-Sensitive and Phosphatidylinositol-3-kinase-Regulated Phospholipase D in a Mast Cell Line J. Pharmacol. Exp. Ther., April 1, 1998; 285(1): 110 - 118. [Abstract] [Full Text]
|
|
|
|
|
|
P. K. Tithof, M. Peters-Golden, and P. E. Ganey Distinct Phospholipases A2 Regulate the Release of Arachidonic Acid for Eicosanoid Production and Superoxide Anion Generation in Neutrophils J. Immunol., January 15, 1998; 160(2): 953 - 960. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Hernandez, S. L. Burillo, M. S. Crespo, and M. L. Nieto Secretory Phospholipase A2 Activates the Cascade of Mitogen-activated Protein Kinases and Cytosolic Phospholipase A2 in the Human Astrocytoma Cell Line 1321N1 J. Biol. Chem., January 2, 1998; 273(1): 606 - 612. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Starkopf, T. V Andreasen, E. Bugge, and K. Ytrehus Lipid peroxidation, arachidonic acid and products of the lipoxygenase pathway in ischaemic preconditioning of rat heart Cardiovasc Res, January 1, 1998; 37(1): 66 - 75. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
U. D. Sohn, K. M. Harnett, W. Cao, H. Rich, N. Kim, J. Behar, and P. Biancani Acute Experimental Esophagitis Activates a Second Signal Transduction Pathway in Cat Smooth Muscle from the Lower Esophageal Sphincter J. Pharmacol. Exp. Ther., December 1, 1997; 283(3): 1293 - 1304. [Abstract] [Full Text]
|
|
|
|
 |
|
 S. B. Ryu, B. H. Karlsson, M. Ozgen, and J. P. Palta Inhibition of phospholipase D by lysophosphatidylethanolamine, a lipid-derived senescence retardant PNAS, November 11, 1997; 94(23): 12717 - 12721. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M.-J. Kang, T. Fujino, H. Sasano, H. Minekura, N. Yabuki, H. Nagura, H. Iijima, and T. T. Yamamoto A novel arachidonate-preferring acyl-CoA synthetase is present in steroidogenic cells of the rat adrenal, ovary, and testis PNAS, April 1, 1997; 94(7): 2880 - 2884. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Bunting, W. Tang, G. A. Zimmerman, T. M. McIntyre, and S. M. Prescott Molecular Cloning and Characterization of a Novel Human Diacylglycerol Kinase [IMAGE] J. Biol. Chem., April 26, 1996; 271(17): 10230 - 10236. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. Balboa, J. Balsinde, E. A. Dennis, and P. A. Insel A Phospholipase D-mediated Pathway for Generating Diacylglycerol in Nuclei from Madin-Darby Canine Kidney Cells J. Biol. Chem., May 19, 1995; 270(20): 11738 - 11740. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Withiam-Leitch, R. P. Rubin, S. E. Koshlukova, and J. M. Aletta Identification and Characterization of Carboxyl Ester Hydrolase as a Phospholipid Hydrolyzing Enzyme of Zymogen Granule Membranes from Rat Exocrine Pancreas J. Biol. Chem., February 24, 1995; 270(8): 3780 - 3787. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y Nishizuka Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C Science, October 23, 1992; 258(5082): 607 - 614. [Abstract] [PDF]
|
|
|
|
|
|
R. A. Cunha, T. Almeida, and J. A. Ribeiro Modification by Arachidonic Acid of Extracellular Adenosine Metabolism and Neuromodulatory Action in the Rat Hippocampus J. Biol. Chem., November 22, 2000; 275(48): 37572 - 37581. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Deregnaucourt and J. Schrevel Bee Venom Phospholipase A2 Induces Stage-specific Growth Arrest of the Intraerythrocytic Plasmodium falciparum via Modifications of Human Serum Components J. Biol. Chem., December 15, 2000; 275(51): 39973 - 39980. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Luo, L. M. Broad, G. St. J. Bird, and J. W. Putney Jr. Signaling Pathways Underlying Muscarinic Receptor-induced [Ca2+]i Oscillations in HEK293 Cells J. Biol. Chem., February 16, 2001; 276(8): 5613 - 5621. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
