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The FASEB Journal, Vol 5, 295-300, Copyright © 1991 by The Federation of American Societies for Experimental Biology

REVIEWS

Nucleotide chloramines and neutrophil-mediated cytotoxicity

C Bernofsky
Department of Biochemistry, Tulane University School of Medicine, New Orleans, Louisiana 70112.

Hypochlorite is a reactive oxidant formed as an end product of the respiratory burst in activated neutrophils. It is responsible for killing bacteria and has been implicated in neutrophil-mediated tissue injury associated with the inflammatory process. Although hypochlorite is a potent cytotoxic agent, the primary mechanism by which it exerts its effect is unclear. This review examines evidence that the primary event in hypochlorite cytotoxicity is the loss of adenine nucleotides from the target cell. This loss appears to be mediated by the formation of adenine nucleotide chloramines which are reactive intermediates with a free radical character and are capable of forming stable ligands with proteins and nucleic acids.


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Copyright © 1991 by The Federation of American Societies for Experimental Biology.