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The FASEB Journal, Vol 5, 211-216, Copyright © 1991 by The Federation of American Societies for Experimental Biology

RESEARCH COMMUNICATIONS

Apoptosis: mode of cell death induced in T cell leukemia lines by dexamethasone and other agents

N Bansal, A Houle and G Melnykovych
Department of Veterans Affairs Medical Center, Kansas City, Missouri 64128.

Glucocorticoids can mediate the destruction of thymocytes and T cell- derived leukemia cells through a mechanism known as apoptosis. The characteristic feature of apoptosis is fragmentation of DNA at internucleosomal linkers through the activity of a specific endonuclease. In this study, an attempt was made to compare dexamethasone-induced apoptosis in two T cell-derived human leukemia lines (CEM-C1 and CEM-C7) to the cell killing brought about by selected cytotoxic agents. In the CEM-C7 cell line (dexamethasone-sensitive), apoptosis was induced not only by dexamethasone but by actinomycin D, cycloheximide, and 25-OH cholesterol. In the CEM-C1 cell line (dexamethasone-resistant) cycloheximide, 25-OH cholesterol, or cell starvation could induce apoptosis. It appears that in leukemic cells apoptosis may be induced by a variety of unrelated toxic agents and is not limited to glucocorticoids.


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Copyright © 1991 by The Federation of American Societies for Experimental Biology.