FASEB J.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Gunning, P.
Right arrow Articles by Hardeman, E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Gunning, P.
Right arrow Articles by Hardeman, E.

The FASEB Journal, Vol 5, 3064-3070, Copyright © 1991 by The Federation of American Societies for Experimental Biology

REVIEWS

Multiple mechanisms regulate muscle fiber diversity

P Gunning and E Hardeman
Cell Biology Unit, Children's Medical Research Foundation, Camperdown N.S.W., Australia.

Adult skeletal muscles are composed of clusters of multinucleated muscle cells called myofibers. At least three different types of myofibers can be detected within mammals based on their physiological properties and their expression of different contractile protein isoforms. Different skeletal muscles display a wide range of combinations of myofibers. Recent work has demonstrated that multiple mechanisms are responsible for the generation of these myofiber types during development. Muscle progenitor cells have been dissected into two categories on the basis of which isoforms of myosin heavy chain (MHC) they express when they differentiate. Neural and other environmental influences act to modify decisions concerning the type of contractile protein a myofiber may express, and this is most apparent for MHC. The other contractile protein gene families are initially regulated independent of the MHC gene family. One or more events late in development are responsible for coordinating isoform expression between the gene families to generate the adult phenotype. Studies of muscle gene expression have revealed that regulation can occur at the levels of transcription, alternative splicing of primary transcripts, mRNA stability, and translation. The current challenge is to decipher how environmental and functional information is interpreted in terms of the activity of the regulators of muscle gene expression.


This article has been cited by other articles:


Home page
 J. Histochem. Cytochem.Home page
K. Eizema, D. E. van der Wal, M. M.M. van den Burg, H. W. de Jonge, and M. E. Everts
Differential Expression of Calcineurin and SR Ca2+ Handling Proteins in Equine Muscle Fibers During Early Postnatal Growth
J. Histochem. Cytochem., March 1, 2007; 55(3): 247 - 254.
[Abstract] [Full Text] [PDF]

Home page
 J. Histochem. Cytochem.Home page
H. W. de Jonge, C. W. van der Wiel, K. Eizema, W. A. Weijs, and M. E. Everts
Presence of SERCA and Calcineurin during Fetal Development of Porcine Skeletal Muscle
J. Histochem. Cytochem., June 1, 2006; 54(6): 641 - 648.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
M. A. Brotto, B. J. Biesiadecki, L. S. Brotto, T. M. Nosek, and J.-P. Jin
Coupled expression of troponin T and troponin I isoforms in single skeletal muscle fibers correlates with contractility
Am J Physiol Cell Physiol, February 1, 2006; 290(2): C567 - C576.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
P. Polly, L. M. Haddadi, L. L. Issa, N. Subramaniam, S. J. Palmer, E. S. E. Tay, and E. C. Hardeman
hMusTRD1{alpha}1 Represses MEF2 Activation of the Troponin I Slow Enhancer
J. Biol. Chem., September 19, 2003; 278(38): 36603 - 36610.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
D. L. Allen, C. A. Sartorius, L. K. Sycuro, and L. A. Leinwand
Different Pathways Regulate Expression of the Skeletal Myosin Heavy Chain Genes
J. Biol. Chem., November 16, 2001; 276(47): 43524 - 43533.
[Abstract] [Full Text] [PDF]

Home page
 J. Exp. Biol.Home page
H. Zakon and G. Unguez
Development and regeneration of the electric organ
J. Exp. Biol., January 5, 1999; 202(10): 1427 - 1434.
[Abstract] [PDF]

Home page
 J. Neurosci.Home page
G. A. Unguez and H. H. Zakon
Reexpression of Myogenic Proteins in Mature Electric Organ after Removal of Neural Input
J. Neurosci., December 1, 1998; 18(23): 9924 - 9935.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
X. A. Bigard, C. Janmot, D. Merino, F. Lienhard, Y. C. Guezennec, and A. D'Albis
Endurance training affects myosin heavy chain phenotype in regenerating fast-twitch muscle
J Appl Physiol, December 1, 1996; 81(6): 2658 - 2665.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
M. Cusella-De Angelis, S Molinari, A Le Donne, M Coletta, E Vivarelli, M Bouche, M Molinaro, S Ferrari, and G Cossu
Differential response of embryonic and fetal myoblasts to TGF beta: a possible regulatory mechanism of skeletal muscle histogenesis
Development, January 4, 1994; 120(4): 925 - 933.
[Abstract] [PDF]

Home page
 DevelopmentHome page
P. Hallauer, H. Bradshaw, and K. Hastings
Complex fiber-type-specific expression of fast skeletal muscle troponin I gene constructs in transgenic mice
Development, January 11, 1993; 119(3): 691 - 701.
[Abstract] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1991 by The Federation of American Societies for Experimental Biology.