FASEB J. Pierce now sold as Thermo Scientific
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Chien, K. R.
Right arrow Articles by Chien, S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Chien, K. R.
Right arrow Articles by Chien, S.

The FASEB Journal, Vol 5, 3037-3046, Copyright © 1991 by The Federation of American Societies for Experimental Biology

REVIEWS

Regulation of cardiac gene expression during myocardial growth and hypertrophy: molecular studies of an adaptive physiologic response

KR Chien, KU Knowlton, H Zhu and S Chien
Department of Medicine, University of California, San Diego 92093.

Studies from both in vivo and in vitro model systems have provided an initial skeleton of the potential signaling pathways that might regulate cardiac genes during growth and hypertrophy. One of the first detectable changes in cardiac gene expression is the activation of a program of immediate early gene expression, which is distinct for the hypertrophic response, and is conserved in multiple models of both in vivo and in vitro hypertrophy. Diverse and distinct hormonal stimuli have been documented to activate several features of the hypertrophic response, including several autocrine and paracrine factors. Although the signaling mechanisms that link these factors with the activation of cardiac gene expression are unclear, recent studies suggest that the activation of protein kinase C may represent one of the most proximal common events in this signaling cascade. The activation of cardiac target genes induces a program of embryonic gene expression, including the atrial natriuretic factor (ANF) gene. The cis sequences that mediate cardiac-specific and inducible expression of an embryonic marker gene (ANF) can be segregated by studies in both cultured cell models and in vivo models of hypertrophy in transgenic mice, suggesting that specific sets of regulatory elements may exist for inducible expression of this class of cardiac gene responses. However, the induction of a constitutively expressed contractile protein gene (MLC- 2) is mediated by a set of conserved elements that regulate both cardiac-specific and inducible expression. Finally, a subset of cardiac muscle genes appears to be noninducible during in vivo or in vitro hypertrophy in myocardial cells, demonstrating specificity of transcriptional activation during the hypertrophic process. The development of a bona fide in vivo pressure overload model of hypertrophy in a small animal model that can be genetically manipulated, such as the in vivo murine model recently described, should allow a rigorous analysis of the role of these specific signaling mechanisms in the activation of the responses of cardiac genes during the hypertrophic process in vivo.


This article has been cited by other articles:


Home page
 J. Biol. Chem.Home page
C. P. Alibin, M. A. Kopilas, and H. D. I. Anderson
Suppression of Cardiac Myocyte Hypertrophy by Conjugated Linoleic Acid: ROLE OF PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS {alpha} AND {gamma}
J. Biol. Chem., April 18, 2008; 283(16): 10707 - 10715.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
T. Takaya, T. Kawamura, T. Morimoto, K. Ono, T. Kita, A. Shimatsu, and K. Hasegawa
Identification of p300-targeted Acetylated Residues in GATA4 during Hypertrophic Responses in Cardiac Myocytes
J. Biol. Chem., April 11, 2008; 283(15): 9828 - 9835.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
T. Horsthuis, A. C. Houweling, P. E.M.H. Habets, F. J. de Lange, H. el Azzouzi, D. E.W. Clout, A. F.M. Moorman, and V. M. Christoffels
Distinct Regulation of Developmental and Heart Disease-Induced Atrial Natriuretic Factor Expression by Two Separate Distal Sequences
Circ. Res., April 11, 2008; 102(7): 849 - 859.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
D. P. Morris, B. Lei, Y.-X. Wu, G. A. Michelotti, and D. A. Schwinn
The {alpha}1a-Adrenergic Receptor Occupies Membrane Rafts with Its G Protein Effectors but Internalizes via Clathrin-coated Pits
J. Biol. Chem., February 1, 2008; 283(5): 2973 - 2985.
[Abstract] [Full Text] [PDF]

Home page
 J EndocrinolHome page
S J. Sangaralingham, M Y. Tse, and S. C Pang
Estrogen protects against the development of salt-induced cardiac hypertrophy in heterozygous proANP gene-disrupted mice
J. Endocrinol., July 1, 2007; 194(1): 143 - 152.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
M. Fernandez-Velasco, G. Ruiz-Hurtado, O. Hurtado, M. A. Moro, and C. Delgado
TNF-{alpha} downregulates transient outward potassium current in rat ventricular myocytes through iNOS overexpression and oxidant species generation
Am J Physiol Heart Circ Physiol, July 1, 2007; 293(1): H238 - H245.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
G. W. Dorn II
The Fuzzy Logic of Physiological Cardiac Hypertrophy
Hypertension, May 1, 2007; 49(5): 962 - 970.
[Full Text] [PDF]

Home page
 HypertensionHome page
D. G. Gardner, S. Chen, D. J. Glenn, and C. L. Grigsby
Molecular Biology of the Natriuretic Peptide System: Implications for Physiology and Hypertension
Hypertension, March 1, 2007; 49(3): 419 - 426.
[Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
D. Xu, N. Li, Y. He, V. Timofeyev, L. Lu, H.-J. Tsai, I.-H. Kim, D. Tuteja, R. K. P. Mateo, A. Singapuri, et al.
Prevention and reversal of cardiac hypertrophy by soluble epoxide hydrolase inhibitors
PNAS, December 5, 2006; 103(49): 18733 - 18738.
[Abstract] [Full Text] [PDF]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
A. Azakie, J. R. Fineman, and Y. He
Myocardial transcription factors are modulated during pathologic cardiac hypertrophy in vivo
J. Thorac. Cardiovasc. Surg., December 1, 2006; 132(6): 1262 - 1271.
[Abstract] [Full Text] [PDF]

Home page
 Nucleic Acids ResHome page
D. A. Glauser and W. Schlegel
Mechanisms of transcriptional regulation underlying temporal integration of signals
Nucleic Acids Res., October 6, 2006; (2006) gkl654v3.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
D. Hilfiker-Kleiner, A. Hilfiker, M. Castellazzi, K. C. Wollert, C. Trautwein, H. Schunkert, and H. Drexler
JunD attenuates phenylephrine-mediated cardiomyocyte hypertrophy by negatively regulating AP-1 transcriptional activity
Cardiovasc Res, July 1, 2006; 71(1): 108 - 117.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
E. S. Montana and J. T. Littleton
Expression Profiling of a Hypercontraction-induced Myopathy in Drosophila Suggests a Compensatory Cytoskeletal Remodeling Response
J. Biol. Chem., March 24, 2006; 281(12): 8100 - 8109.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
E. Morel, A. Marcantoni, M. Gastineau, R. Birkedal, F. Rochais, A. Garnier, A.-M. Lompre, G. Vandecasteele, and F. Lezoualc'h
cAMP-Binding Protein Epac Induces Cardiomyocyte Hypertrophy
Circ. Res., December 9, 2005; 97(12): 1296 - 1304.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
C. A. Petersen, K. A. Krumholz, and B. A. Burleigh
Toll-Like Receptor 2 Regulates Interleukin-1{beta}-Dependent Cardiomyocyte Hypertrophy Triggered by Trypanosoma cruzi
Infect. Immun., October 1, 2005; 73(10): 6974 - 6980.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
N. Wettschureck and S. Offermanns
Mammalian G Proteins and Their Cell Type Specific Functions
Physiol Rev, October 1, 2005; 85(4): 1159 - 1204.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
A. C. Houweling, M. M. van Borren, A. F.M. Moorman, and V. M. Christoffels
Expression and regulation of the atrial natriuretic factor encoding gene Nppa during development and disease
Cardiovasc Res, September 1, 2005; 67(4): 583 - 593.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
D. Gurantz, A. Yndestad, B. Halvorsen, O. V. Lunde, J. H. Omens, T. Ueland, P. Aukrust, C. D. Moore, J. Kjekshus, and B. H. Greenberg
Etanercept or intravenous immunoglobulin attenuates expression of genes involved in post-myocardial infarction remodeling
Cardiovasc Res, July 1, 2005; 67(1): 106 - 115.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
M.-C. Battista, E. Calvo, A. Chorvatova, B. Comte, J. Corbeil, and M. Brochu
Intra-uterine growth restriction and the programming of left ventricular remodelling in female rats
J. Physiol., May 15, 2005; 565(1): 197 - 205.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. ProteomicsHome page
T. M. Casey, P. G. Arthur, and M. A. Bogoyevitch
Proteomic Analysis Reveals Different Protein Changes during Endothelin-1- or Leukemic Inhibitory Factor-induced Hypertrophy of Cardiomyocytes in Vitro
Mol. Cell. Proteomics, May 1, 2005; 4(5): 651 - 661.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
G. Klein, A. Schaefer, D. Hilfiker-Kleiner, D. Oppermann, P. Shukla, A. Quint, E. Podewski, A. Hilfiker, F. Schroder, M. Leitges, et al.
Increased Collagen Deposition and Diastolic Dysfunction but Preserved Myocardial Hypertrophy After Pressure Overload in Mice Lacking PKC{epsilon}
Circ. Res., April 15, 2005; 96(7): 748 - 755.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
C. Poizat, P. L. Puri, Y. Bai, and L. Kedes
Phosphorylation-Dependent Degradation of p300 by Doxorubicin-Activated p38 Mitogen-Activated Protein Kinase in Cardiac Cells
Mol. Cell. Biol., April 1, 2005; 25(7): 2673 - 2687.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
W. Xiang, J. Kong, S. Chen, L.-P. Cao, G. Qiao, W. Zheng, W. Liu, X. Li, D. G. Gardner, and Y. C. Li
Cardiac hypertrophy in vitamin D receptor knockout mice: role of the systemic and cardiac renin-angiotensin systems
Am J Physiol Endocrinol Metab, January 1, 2005; 288(1): E125 - E132.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Biol.Home page
R. Arya, V. Kedar, J. R. Hwang, H. McDonough, H.-H. Li, J. Taylor, and C. Patterson
Muscle ring finger protein-1 inhibits PKC{epsilon} activation and prevents cardiomyocyte hypertrophy
J. Cell Biol., December 20, 2004; 167(6): 1147 - 1159.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. Mathew, E. Mascareno, and M. A. Q. Siddiqui
A Ternary Complex of Transcription Factors, Nished and NFATc4, and Co-activator p300 Bound to an Intronic Sequence, Intronic Regulatory Element, Is Pivotal for the Up-regulation of Myosin Light Chain-2v Gene in Cardiac Hypertrophy
J. Biol. Chem., September 24, 2004; 279(39): 41018 - 41027.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
D. Onan, L. Pipolo, E. Yang, R. D. Hannan, and W. G. Thomas
Urotensin II Promotes Hypertrophy of Cardiac Myocytes via Mitogen-Activated Protein Kinases
Mol. Endocrinol., September 1, 2004; 18(9): 2344 - 2354.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
Y. Xia and M. Karmazyn
Obligatory Role for Endogenous Endothelin in Mediating the Hypertrophic Effects of Phenylephrine and Angiotensin II in Neonatal Rat Ventricular Myocytes: Evidence for Two Distinct Mechanisms for Endothelin Regulation
J. Pharmacol. Exp. Ther., July 1, 2004; 310(1): 43 - 51.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
O. Tenhunen, B. Sarman, R. Kerkela, I. Szokodi, L. Papp, M. Toth, and H. Ruskoaho
Mitogen-activated Protein Kinases p38 and ERK 1/2 Mediate the Wall Stress-induced Activation of GATA-4 Binding in Adult Heart
J. Biol. Chem., June 4, 2004; 279(23): 24852 - 24860.
[Abstract] [Full Text] [PDF]

Home page
 Journal of Renin-Angiotensin-Aldosterone SystemHome page
M. Kurdi, C. Cerutti, J. Randon, L. McGregor, and G. Bricca
Macroarray analysis in the hypertrophic left ventricle of renin-dependent hypertensive rats: identification of target genes for renin
Journal of Renin-Angiotensin-Aldosterone System, June 1, 2004; 5(2): 72 - 78.
[Abstract] [PDF]

Home page
 Ann. N. Y. Acad. Sci.Home page
G. W. DORN II and H. S. HAHN
Genetic Factors in Cardiac Hypertrophy
Ann. N.Y. Acad. Sci., May 1, 2004; 1015(1): 225 - 237.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
W. L. Davies, J. I. Vandenberg, R. A. Sayeed, and A. E. O. Trezise
Cardiac Expression of the Cystic Fibrosis Transmembrane Conductance Regulator Involves Novel Exon 1 Usage to Produce a Unique Amino-terminal Protein
J. Biol. Chem., April 16, 2004; 279(16): 15877 - 15887.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Biol. CellHome page
B. Baeza-Raja and P. Munoz-Canoves
p38 MAPK-induced Nuclear Factor-{kappa}B Activity Is Required for Skeletal Muscle Differentiation: Role of Interleukin-6
Mol. Biol. Cell, April 1, 2004; 15(4): 2013 - 2026.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
H. D. I. Anderson, F. Wang, and D. G. Gardner
Role of the Epidermal Growth Factor Receptor in Signaling Strain-dependent Activation of the Brain Natriuretic Peptide Gene
J. Biol. Chem., March 5, 2004; 279(10): 9287 - 9297.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
Y. Pan, T. Kislinger, A. O. Gramolini, E. Zvaritch, E. G. Kranias, D. H. MacLennan, and A. Emili
Identification of biochemical adaptations in hyper- or hypocontractile hearts from phospholamban mutant mice by expression proteomics
PNAS, February 24, 2004; 101(8): 2241 - 2246.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
F. A. Babiker, L. J. De Windt, M. van Eickels, V. Thijssen, R. J.P. Bronsaer, C. Grohe, M. van Bilsen, and P. A. Doevendans
17{beta}-Estradiol Antagonizes Cardiomyocyte Hypertrophy by Autocrine/Paracrine Stimulation of a Guanylyl Cyclase A Receptor-Cyclic Guanosine Monophosphate-Dependent Protein Kinase Pathway
Circulation, January 20, 2004; 109(2): 269 - 276.
[Abstract] [Full Text] [PDF]

Home page
 Ann. N. Y. Acad. Sci.Home page
S MUKADDAM-DAHER, A MENAOUAR, R EL-AYOUBI, J GUTKOWSKA, M JANKOWSKI, R. VELLIQUETTE, and P ERNSBERGER
Cardiac Effects of Moxonidine in Spontaneously Hypertensive Obese Rats
Ann. N.Y. Acad. Sci., December 1, 2003; 1009(1): 244 - 250.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. GenomicsHome page
M. Mirotsou, C. M.H. Watanabe, P. G. Schultz, R. E. Pratt, and V. J. Dzau
Elucidating the molecular mechanism of cardiac remodeling using a comparative genomic approach
Physiol Genomics, October 17, 2003; 15(2): 115 - 126.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
A. F. M. MOORMAN and V. M. CHRISTOFFELS
Cardiac Chamber Formation: Development, Genes, and Evolution
Physiol Rev, October 1, 2003; 83(4): 1223 - 1267.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
C. Weikert, M. Eppenberger-Eberhardt, and H. M Eppenberger
Cellular engineering of ventricular adult rat cardiomyocytes
Cardiovasc Res, October 1, 2003; 59(4): 874 - 882.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
F. Liang, F. Wang, S. Zhang, and D. G. Gardner
Peroxisome Proliferator Activated Receptor (PPAR){alpha} Agonists Inhibit Hypertrophy of Neonatal Rat Cardiac Myocytes
Endocrinology, September 1, 2003; 144(9): 4187 - 4194.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
A. Ponten, X. Li, P. Thoren, K. Aase, T. Sjoblom, A. Ostman, and U. Eriksson
Transgenic Overexpression of Platelet-Derived Growth Factor-C in the Mouse Heart Induces Cardiac Fibrosis, Hypertrophy, and Dilated Cardiomyopathy
Am. J. Pathol., August 1, 2003; 163(2): 673 - 682.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. Pikkarainen, H. Tokola, T. Majalahti-Palviainen, R. Kerkela, N. Hautala, S. S. Bhalla, F. Charron, M. Nemer, O. Vuolteenaho, and H. Ruskoaho
GATA-4 Is a Nuclear Mediator of Mechanical Stretch-activated Hypertrophic Program
J. Biol. Chem., June 20, 2003; 278(26): 23807 - 23816.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
G. W. Dorn II, J. Robbins, and P. H. Sugden
Phenotyping Hypertrophy: Eschew Obfuscation
Circ. Res., June 13, 2003; 92(11): 1171 - 1175.
[Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
J. C. Borges, J. A. Silva Jr., M. A. Gomes, E. S. L. Lomez, K. M. Leite, R. C. Araujo, M. Bader, J. B. Pesquero, and J. L. Pesquero
Tonin in rat heart with experimental hypertrophy
Am J Physiol Heart Circ Physiol, June 1, 2003; 284(6): H2263 - H2268.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. Krenz, A. Sanbe, F. Bouyer-Dalloz, J. Gulick, R. Klevitsky, T. E. Hewett, H. E. Osinska, J. N. Lorenz, C. Brosseau, A. Federico, et al.
Analysis of Myosin Heavy Chain Functionality in the Heart
J. Biol. Chem., May 2, 2003; 278(19): 17466 - 17474.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
T. Jalili, J. Manning, and S. Kim
Increased Translocation of Cardiac Protein Kinase C {beta}2 Accompanies Mild Cardiac Hypertrophy in Rats Fed Saturated Fat
J. Nutr., February 1, 2003; 133(2): 358 - 361.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
J. Yun, M. J Zuscik, P. Gonzalez-Cabrera, D. F McCune, S. A Ross, R. Gaivin, M. T Piascik, and D. M Perez
Gene expression profiling of {alpha}1b-adrenergic receptor-induced cardiac hypertrophy by oligonucleotide arrays
Cardiovasc Res, February 1, 2003; 57(2): 443 - 455.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. Pikkarainen, H. Tokola, R. Kerkela, T. Majalahti-Palviainen, O. Vuolteenaho, and H. Ruskoaho
Endothelin-1-specific Activation of B-type Natriuretic Peptide Gene via p38 Mitogen-activated Protein Kinase and Nuclear ETS Factors
J. Biol. Chem., January 31, 2003; 278(6): 3969 - 3975.
[Abstract] [Full Text] [PDF]

Home page
 Card Surg AdultHome page
T. Mihaljevic, S. Paul, L. H. Cohn, and A. Wechsler
Pathophysiology of Aortic Valve Disease
Card. Surg. Adult, January 1, 2003; 2(2003): 791 - 810.
[Full Text]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
J. N. Tsoporis, A. Marks, L. J. Van Eldik, D. O'Hanlon, and T. G. Parker
Regulation of the S100B gene by alpha 1-adrenergic stimulation in cardiac myocytes
Am J Physiol Heart Circ Physiol, January 1, 2003; 284(1): H193 - H203.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Biol.Home page
S. Gupta, N. H. Purcell, A. Lin, and S. Sen
Activation of nuclear factor-{kappa}B is necessary for myotrophin-induced cardiac hypertrophy
J. Cell Biol., December 23, 2002; 159(6): 1019 - 1028.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
H. S. Hahn, M. G. Yussman, T. Toyokawa, Y. Marreez, T. J. Barrett, K. C. Hilty, H. Osinska, J. Robbins, and G. W. Dorn II
Ischemic Protection and Myofibrillar Cardiomyopathy: Dose-Dependent Effects of In Vivo {delta}PKC Inhibition
Circ. Res., October 18, 2002; 91(8): 741 - 748.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
T. Delhaas, S. van Engeland, J. Broers, C. Bouten, N. Kuijpers, F. Ramaekers, and L. H. E. H. Snoeckx
Quantification of cytoskeletal deformation in living cells based on hierarchical feature vector matching
Am J Physiol Cell Physiol, August 1, 2002; 283(2): C639 - C645.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
M.-C. Battista, L. L. Oligny, J. St-Louis, and M. Brochu
Intrauterine growth restriction in rats is associated with hypertension and renal dysfunction in adulthood
Am J Physiol Endocrinol Metab, July 1, 2002; 283(1): E124 - E131.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
G. R. Post, C. Swiderski, B. A. Waldrop, L. Salty, C. C. Glembotski, R. M. F. Wolthuis, and N. Mochizuki
Guanine Nucleotide Exchange Factor-like Factor (Rlf) Induces Gene Expression and Potentiates alpha 1-Adrenergic Receptor-induced Transcriptional Responses in Neonatal Rat Ventricular Myocytes
J. Biol. Chem., May 3, 2002; 277(18): 15286 - 15292.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
R. Kerkela, S. Pikkarainen, T. Majalahti-Palviainen, H. Tokola, and H. Ruskoaho
Distinct Roles of Mitogen-activated Protein Kinase Pathways in GATA-4 Transcription Factor-mediated Regulation of B-type Natriuretic Peptide Gene
J. Biol. Chem., April 12, 2002; 277(16): 13752 - 13760.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
T. Yanazume, K. Hasegawa, H. Wada, T. Morimoto, M. Abe, T. Kawamura, and S. Sasayama
Rho/ROCK Pathway Contributes to the Activation of Extracellular Signal-regulated Kinase/GATA-4 during Myocardial Cell Hypertrophy
J. Biol. Chem., March 1, 2002; 277(10): 8618 - 8625.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
U. Laufs, H. Kilter, C. Konkol, S. Wassmann, M. Bohm, and G. Nickenig
Impact of HMG CoA reductase inhibition on small GTPases in the heart
Cardiovasc Res, March 1, 2002; 53(4): 911 - 920.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
K. L. Peterson
Pressure overload hypertrophy and congestive heart failure: Where is the "Achilles' heel"?
J. Am. Coll. Cardiol., February 20, 2002; 39(4): 672 - 675.
[Full Text] [PDF]

Home page
 Mol. Pharmacol.Home page
S. W. Bahouth, M. J. Beauchamp, and K. N. Vu
Reciprocal Regulation of beta 1-Adrenergic Receptor Gene Transcription by Sp1 and Early Growth Response Gene 1: Induction of EGR-1 Inhibits the Expression of the beta 1-Adrenergic Receptor Gene
Mol. Pharmacol., February 1, 2002; 61(2): 379 - 390.
[Abstract] [Full Text] [PDF]