The FASEB Journal, Vol 5, 2934-2944, Copyright © 1991 by The Federation of American Societies for Experimental Biology

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Site-specific recombination in the immune system

MR Lieber
Department of Pathology, Stanford University School of Medicine, California 94305-5324.

Site-specific DNA recombination has been identified in a wide variety of biological systems. In vertebrates, however, the only identified use of this genetic device is in the immune system. Here it plays a critical role in generating a diverse repertoire of surface receptors to intercept invading microbes and parasites. The mechanism and orchestration of this reaction are intriguing and are relevant to a broad array of related biological and biomedical issues.

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