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The FASEB Journal, Vol 5, 2916-2923, Copyright © 1991 by The Federation of American Societies for Experimental Biology

REVIEWS

GABAA receptor subtypes: from pharmacology to molecular biology

DR Burt and GL Kamatchi
Department of Pharmacology and Experimental Therapeutics, University of Maryland School of Medicine, Baltimore 21201.

GABAA receptors are GABA (gamma-aminobutyric acid)-gated chloride channels, which are major mediators of neuronal inhibition in the brain and are modulated by benzodiazepines, barbiturates, alcohol, and other important centrally acting drugs. Although previous pharmacological and biochemical data had suggested a degree of heterogeneity, recent cloning of at least 15 different receptor subunits, thought to be combined in groups of five, indicates that the brain may contain a truly astonishing variety of GABAA receptor subtypes. This review describes the little that is known about these subtypes, emphasizing possible molecular bases of receptor heterogeneity. We also discuss approaches to establishing the subunit composition of subtypes.


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Copyright © 1991 by The Federation of American Societies for Experimental Biology.