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The FASEB Journal, Vol 5, 2699-2705, Copyright © 1991 by The Federation of American Societies for Experimental Biology

REVIEWS

Antigen specificity of gamma delta T lymphocytes

WK Born, RL O'Brien and RL Modlin
Department of Medicine, National Jewish Center for Immunology and Respiratory Medicine, Denver, Colorado 80206.

gamma delta T cells represent a new lymphocyte subset without a definitive functional assignment. Although in many ways similar to alpha beta T lymphocytes, they are clearly distinguished by their expression of a different set of T cell receptor genes, a different distribution in normal tissues, and perhaps also different ligand specificities. Because gamma delta T cells appear to be involved in a variety of human diseases, the determination of their biological role has become an important challenge for immunologists and researchers in related areas.


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