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The FASEB Journal, Vol 5, 2547-2553, Copyright © 1991 by The Federation of American Societies for Experimental Biology

REVIEWS

Role of B cell antigen processing and presentation in the humoral immune response [published erratum appears in FASEB J 1991 Oct;5(13):2867]

CD Myers
Department of Microbiology and Immunology, University of Tennessee, Memphis 38163.

In the 25 years since it was first indicated that lymphocyte subpopulations must interact during the generation of a humoral immune response, there has been an explosion of data on the molecular mechanism of this interaction. It has been demonstrated that T cells recognize a processed antigen fragment presented by a major histocompatibility complex molecule on the surface of an antigen- presenting cell. The minimal peptides required for T cell recognition of several proteins have been determined, the molecular genetics of many of the cell surface molecules involved have been defined, and the three-dimensional structure of the T cell receptor and the major histocompatibility antigens have been deduced. Several cell types have been found to act as antigen-presenting cells, although the roles of these populations in vivo remain unclear. However, it is clear that there must be a physical interaction between a B cell and a T cell before the B cell can respond to a T-dependent antigen. This interaction requires processing and presentation of the antigen by the B cell. Therefore this review focuses on antigen processing and presentation by resting B cells, one of the key steps in initiation of a humoral immune response.


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Copyright © 1991 by The Federation of American Societies for Experimental Biology.