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The FASEB Journal, Vol 5, 28-34, Copyright © 1991 by The Federation of American Societies for Experimental Biology

REVIEWS

New techniques for physical mapping of the human genome

PR Billings, CL Smith and CR Cantor
Human Genome Center, Lawrence Berkeley Laboratory, Berkeley, California 94720.

We describe improvements in techniques and strategies used for making maps of the human genome. The methods currently used are changing and evolving rapidly. Today's techniques can produce ordered arrays of DNA fragments and overlapping sets of DNA clones covering extensive genomic regions, but they are relatively slow and tedious. Methods under development will speed the process considerably. New developments include a range of applications of the polymerase chain reaction, enhanced procedures for high resolution in situ hybridization, and improved methods for generating, manipulating, and cloning large DNA fragments. More detailed genetic and physical maps will be useful for finding genes, including those associated with human diseases, long before the complete DNA sequence of the human genome is available.


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D Shalon, S J Smith, and P O Brown
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Genome Res., July 1, 1996; 6(7): 639 - 645.
[Abstract] [PDF]


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Copyright © 1991 by The Federation of American Societies for Experimental Biology.