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The FASEB Journal, Vol 4, 2511-2517, Copyright © 1990 by The Federation of American Societies for Experimental Biology

RESEARCH COMMUNICATIONS

Upregulation of serum retinol in experimental acute renal failure

TH Gerlach and MH Zile
Department of Food Science and Human Nutrition, Michigan State University, East Lansing 48824-1224.

Serum vitamin A homeostasis was studied in rats with nonfiltering kidneys prepared by ligation of renal arteries. Within 1-2 h of acute renal failure, the serum retinol level increased by 11-73% and was maintained for at least 4 h. More than 90% of the increase in serum retinol was associated with retinol in the retinol binding protein- transthyretin (RBP-TTR) complex. The activities of acyl-CoA:retinol acyltransferase and retinyl-palmitate hydrolase were not altered by short-term acute renal failure. Oral administration of 3H-labeled retinol 3 h before surgery resulted in 350% more tritium in the serum retinol-RBP-TTR complex of rats with acute renal failure as compared to sham-operated rats; this increase represented the fraction of retinol in RBP-TTR contributed by hepatic retinol from newly absorbed 3H- labeled retinol. Total retinol in the retinol-RBP-TTR complex was increased by only 60%. We conclude that short-term acute renal failure causes rapid upregulation of serum retinol-RBP-TTR; the extent of the increase depends on the magnitude of hepatic vitamin A stores, particularly the retinol pools. We hypothesize that kidney modulates the regulation of hepatic release of retinol-RBP from the pool of newly acquired retinol.


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Copyright © 1990 by The Federation of American Societies for Experimental Biology.