FASEB J.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Thomas, J. B.
Right arrow Articles by Crews, S. T.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Thomas, J. B.
Right arrow Articles by Crews, S. T.

The FASEB Journal, Vol 4, 2476-2482, Copyright © 1990 by The Federation of American Societies for Experimental Biology

REVIEWS

Molecular genetics of neuronal development in the Drosophila embryo

JB Thomas and ST Crews
Salk Institute for Biological Studies, San Diego, California 92138.

Making a functional nervous system involves the production of specific types of neurons in characteristic locations and their ability to find and synapse with appropriate target cells. By capitalizing on the advanced genetics and molecular biology of Drosophila, a rapidly growing number of genes have been identified that control these events. Studies of the expression and function of these genes in single, uniquely identified cells is possible because of the relative simplicity of the Drosophila embryonic nervous system. A class of neurogenic genes, including N, Dl, and E(spl), controls the emergence of the entire neuronal precursor population, whereas some of the segmentation genes, such as ftz and eve, control the fates of individual neurons. Later in development, genes encoding cell-surface molecules, called fasciclins, may be involved in the ability of growing neurons to recognize and elongate axons along specific pathways to reach their synaptic targets.


This article has been cited by other articles:


Home page
 J. Biol. Chem.Home page
B.-K. Koo, K.-J. Yoon, K.-W. Yoo, H.-S. Lim, R. Song, J.-H. So, C.-H. Kim, and Y.-Y. Kong
Mind Bomb-2 Is an E3 Ligase for Notch Ligand
J. Biol. Chem., June 10, 2005; 280(23): 22335 - 22342.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1990 by The Federation of American Societies for Experimental Biology.