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The FASEB Journal, Vol 4, 1634-1637, Copyright © 1990 by The Federation of American Societies for Experimental Biology

RESEARCH COMMUNICATIONS

Cellular stress induces a redistribution of the glucose transporter

CC Widnell, SA Baldwin, A Davies, S Martin and CA Pasternak
Department of Neurobiology, University of Pittsburgh School of Medicine, Pennsylvania 15261.

The mechanism by which cells increase their rate of glucose uptake in response to stress is unclear. Using an immunofluorescence technique to localize the glucose transporter protein in BHK cells, we found that hyperthermia, treatment with arsenite, infection with vesicular stomatitis virus or Semliki Forest virus, and treatment with insulin cause the transporter to move from an intracellular site in the perinuclear region to the plasma membrane; the degree of translocation correlates approximately with the increase in glucose uptake. We conclude that stress induces an insulin-like distribution of certain membrane proteins.


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