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The FASEB Journal, Vol 4, 176-187, Copyright © 1990 by The Federation of American Societies for Experimental Biology

REVIEWS

Liver regeneration: molecular mechanisms of growth control

GK Michalopoulos
Department of Pathology, Duke University, Durham, North Carolina 27710.

The molecular signals controlling liver regeneration are becoming rapidly defined. Control of growth in regenerating liver has advanced from elusive serum factors and nutrient effects to identification of entirely new growth factors with apparent liver specificity as well as establishment of meaningful gene expression patterns for growth factors already known. Based on studies with hepatocyte cultures and gene expression in regenerating liver, the substances EGF, TGF alpha, HBGF-1 (aFGF), and two new substances (HPTA/HGF and Hepatopoietin B) have been defined as complete mitogens for hepatocytes and implicated in control of liver growth. The amino acid sequence of HPTA/HGF recently became clear and revealed interesting structural homologies in a molecule that might become the largest known growth factor. The plasticity of growth responses seen in liver may be controlled by these factors as well as by comitogenic substances such as norepinephrine which, although nonmitogenic per se, can initiate growth in hepatocytes exposed to the above mitogenic growth factors or mitogenic inhibitors such as TGF beta. The role of the latter in cessation of DNA synthesis in liver regeneration will be discussed, presenting the positive and negative evidence that constitutes the TGF beta paradox of liver regeneration.


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Home page
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Home page
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[Abstract] [Full Text]

Home page
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[Abstract] [Full Text] [PDF]

Home page
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[Abstract] [Full Text] [PDF]

Home page
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[Abstract]

Home page
 J. Biol. Chem.Home page
P. Loyer, S. Cariou, D. Glaise, M. Bilodeau, G. Baffet, and C. Guguen-Guillouzo
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[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
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J. Biol. Chem., April 5, 1996; 271(14): 8221 - 8227.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
A. M. Diehl, D. C. Johns, S. Yang, H. Lin, M. Yin, L. A. Matelis, and J. H. Lawrence
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J. Biol. Chem., March 29, 1996; 271(13): 7343 - 7350.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
B. Rana, Y. Xie, D. Mischoulon, N. L. R. Bucher, and S. R. Farmer
The DNA Binding Activity of C/EBP Transcription Factors Is Regulated in the G[IMAGE] Phase of the Hepatocyte Cell Cycle
J. Biol. Chem., July 28, 1995; 270(30): 18123 - 18132.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
E. J. Kilbourne, R. Widom, D. C. Harnish, S. Malik, and S. K. Karathanasis
Involvement of Early Growth Response Factor Egr-1 in Apolipoprotein AI Gene Transcription
J. Biol. Chem., March 24, 1995; 270(12): 7004 - 7010.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
J. Soriano, M. Pepper, T Nakamura, L Orci, and R Montesano
Hepatocyte growth factor stimulates extensive development of branching duct-like structures by cloned mammary gland epithelial cells
J. Cell Sci., January 2, 1995; 108(2): 413 - 430.
[Abstract] [PDF]

Home page
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J. Rhim, E. Sandgren, J. Degen, R. Palmiter, and R. Brinster
Replacement of diseased mouse liver by hepatic cell transplantation
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[Abstract] [PDF]

Home page
 ScienceHome page
I Tsarfaty, S Rong, J. Resau, S Rulong, P. da Silva, and G. Vande Woude
The Met proto-oncogene mesenchymal to epithelial cell conversion
Science, January 7, 1994; 263(5143): 98 - 101.
[Abstract] [PDF]

Home page
 ScienceHome page
I Tsarfaty, J. Resau, S Rulong, I Keydar, D. Faletto, and G. Vande Woude
The met proto-oncogene receptor and lumen formation
Science, August 28, 1992; 257(5074): 1258 - 1261.
[Abstract] [PDF]

Home page
 ScienceHome page
D. Bottaro, J. Rubin, D. Faletto, A. Chan, T. Kmiecik, G. Vande Woude, and S. Aaronson
Identification of the hepatocyte growth factor receptor as the c-met proto-oncogene product
Science, February 15, 1991; 251(4995): 802 - 804.
[Abstract] [PDF]

Home page
 J. Biol. Chem.Home page
J. Wu, S.-L. Liu, J.-L. Zhu, P. A. Norton, S. Nojiri, J. B. Hoek, and M. A. Zern
Roles of Tissue Transglutaminase in Ethanol-induced Inhibition of Hepatocyte Proliferation and alpha 1-Adrenergic Signal Transduction
J. Biol. Chem., July 14, 2000; 275(29): 22213 - 22219.
[Abstract] [Full Text] [PDF]

Home page
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