FASEB J.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Green, P. L.
Right arrow Articles by Chen, I. S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Green, P. L.
Right arrow Articles by Chen, I. S.

The FASEB Journal, Vol 4, 169-175, Copyright © 1990 by The Federation of American Societies for Experimental Biology

REVIEWS

Regulation of human T cell leukemia virus expression

PL Green and IS Chen
Department of Microbiology, UCLA School of Medicine 90024-1678.

Retroviruses of the type C morphology have been implicated in a wide variety of diseases in animals and humans. The human T cell leukemia viruses types I (HTLV-I) and II (HTLV-II), the prototypic human-type C retroviruses, have been identified as the causative agents of some forms of human leukemia and neurological disorders. The genetic structure and regulation of the HTLVs are more complex than their avian and murine leukemia virus counterparts. In addition to the gag, pol, and env genes that encode the characteristic virion proteins of all replication competent retroviruses, the genomes of HTLV encode the non- structural proteins, Tax and Rex, which are required for regulating viral gene expression. To understand what appears to be a complex mechanism of disease induction by HTLV, elucidating the regulation and function of the viral gene products and the interaction of these products with each other, as well as with cellular factors, will be critical. This review focuses primarily on regulation of HTLV gene expression in the infected human T lymphocyte, but also discusses analogous gene regulation by the human immunodeficiency virus (HIV). It concentrates specifically on the role these gene products play in virus replication and, ultimately, pathogenesis.


This article has been cited by other articles:


Home page
 J. Biol. Chem.Home page
J.-M. Peloponese Jr. and K.-T. Jeang
Role for Akt/Protein Kinase B and Activator Protein-1 in Cellular Proliferation Induced by the Human T-cell Leukemia Virus Type 1 Tax Oncoprotein
J. Biol. Chem., March 31, 2006; 281(13): 8927 - 8938.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
J.-M. Peloponese Jr., K. Haller, A. Miyazato, and K.-T. Jeang
Abnormal centrosome amplification in cells through the targeting of Ran-binding protein-1 by the human T cell leukemia virus type-1 Tax oncoprotein
PNAS, December 27, 2005; 102(52): 18974 - 18979.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
J.-M. Peloponese Jr., H. Iha, V. R. K. Yedavalli, A. Miyazato, Y. Li, K. Haller, M. Benkirane, and K.-T. Jeang
Ubiquitination of Human T-Cell Leukemia Virus Type 1 Tax Modulates Its Activity
J. Virol., November 1, 2004; 78(21): 11686 - 11695.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
S. M. P. Marques, J.-L. Veyrune, R. R. Shukla, and A. Kumar
Restriction of Human Immunodeficiency Virus Type 1 Rev Function in Murine A9 Cells Involves the Rev C-Terminal Domain
J. Virol., March 1, 2003; 77(5): 3084 - 3090.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S. Sharma, N. Grandvaux, Y. Mamane, P. Genin, N. Azimi, T. Waldmann, and J. Hiscott
Regulation of IFN Regulatory Factor 4 Expression in Human T Cell Leukemia Virus-I-Transformed T Cells
J. Immunol., September 15, 2002; 169(6): 3120 - 3130.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
C. Casoli, E. Vicenzi, A. Cimarelli, G. Magnani, P. Ciancianaini, E. Cattaneo, P. Dall'Aglio, G. Poli, and U. Bertazzoni
HTLV-II down-regulates HIV-1 replication in IL-2-stimulated primary PBMC of coinfected individuals through expression of MIP-1alpha
Blood, May 1, 2000; 95(9): 2760 - 2769.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
E. W. Harhaj and S.-C. Sun
IKKgamma Serves as a Docking Subunit of the Ikappa B Kinase (IKK) and Mediates Interaction of IKK with the Human T-cell Leukemia Virus Tax Protein
J. Biol. Chem., August 13, 1999; 274(33): 22911 - 22914.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. Uhlik, L. Good, G. Xiao, E. W. Harhaj, E. Zandi, M. Karin, and S.-C. Sun
NF-kappa B-inducing Kinase and Ikappa B Kinase Participate in Human T-cell Leukemia Virus I Tax-mediated NF-kappa B Activation
J. Biol. Chem., August 14, 1998; 273(33): 21132 - 21136.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
L. Good, S. B. Maggirwar, E. W. Harhaj, and S.-C. Sun
Constitutive Dephosphorylation and Activation of a Member of the Nuclear Factor of Activated T Cells, NF-AT1, in Tax-expressing and Type I Human T-cell Leukemia Virus-infected Human T Cells
J. Biol. Chem., January 17, 1997; 272(3): 1425 - 1428.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1990 by The Federation of American Societies for Experimental Biology.