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The FASEB Journal, Vol 4, 3131-3134, Copyright © 1990 by The Federation of American Societies for Experimental Biology
RESEARCH COMMUNICATIONS |
JE Maguire, SA McCarthy, A Singer and DS Singer
Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892.
The relationship between steady-state RNA and cell surface levels of T cell receptor (TCR) was examined in mature T cells and immature CD4+CD8+ double positive thymocytes. TCR is expressed at high levels on the surface of mature T cells and at much lower levels on double positive thymocytes. We demonstrate that in direct contrast to surface expression, TCR-alpha, -beta, CD3-delta, -epsilon, -gamma, and sigma RNA levels are much higher in the immature double positive thymocyte population than in mature T cells. These results demonstrate that quantitative differences in TCR surface expression in immature and mature T cells are not due to increases in TCR RNA levels.
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