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The FASEB Journal, Vol 4, 3015-3020, Copyright © 1990 by The Federation of American Societies for Experimental Biology

RESEARCH COMMUNICATIONS

Mosquito oostatic factor: a novel decapeptide modulating trypsin-like enzyme biosynthesis in the midgut

D Borovsky, DA Carlson, PR Griffin, J Shabanowitz and DF Hunt
Institute of Food and Agricultural Sciences, University of Florida, Vero Beach 32962.

A peptide that inhibits egg development in mosquitoes (oostatic factor) has been purified from the ovaries of female Aedes aegypti. The factor is a decapeptide with a molecular mass of 1047.6. The primary sequence has been determined as NH2-Tyr-Asp-Pro-Ala-Pro-Pro-Pro-Pro-Pro-Pro-COOH from mass spectra recorded on a quadrupole Fourier transform instrument. The amino acid sequence exhibits sequence correlation to mammalian, plant, and several viral proteins. Injection of synthetic analogs into mosquitoes, biting midges, flies, and fleas inhibited proteolytic enzyme biosynthesis in the midgut. Binding studies with [3H]oostatic factor indicated that the midgut epithelial cells have a factor-specific receptor.


This article has been cited by other articles:


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 Proc. Natl. Acad. Sci. USAHome page
D. Borovsky, S. Rabindran, W. O. Dawson, C. A. Powell, D. A. Iannotti, T. J. Morris, J. Shabanowitz, D. F. Hunt, H. L. DeBondt, and A. DeLoof
Expression of Aedes trypsin-modulating oostatic factor on the virion of TMV: A potential larvicide
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[Abstract] [Full Text] [PDF]

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 J. Exp. Biol.Home page
D. Borovsky
Trypsin-modulating oostatic factor: a potential new larvicide for mosquito control
J. Exp. Biol., November 1, 2003; 206(21): 3869 - 3875.
[Abstract] [Full Text] [PDF]


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Copyright © 1990 by The Federation of American Societies for Experimental Biology.