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The FASEB Journal, Vol 3, 2086-2088, Copyright © 1989 by The Federation of American Societies for Experimental Biology


RESEARCH COMMUNICATIONS

Similarity between tyrosyl-tRNA synthetase and the estrogen receptor

ME Baker
Department of Medicine, University of California, San Diego, La Jolla 92093.

Residues 1-42 of Escherichia coli tyrosyl-tRNA synthetase are similar to residues 293-334 of the human estrogen receptor. A computer analysis yields a comparison score that is 8.2 standard deviations higher than that obtained with 10,000 comparisons of randomized sequences of these segments (P = 1.2 X 10(-16). This part of tyrosyl-tRNA synthetase binds ATP, which suggests that residues 293-334 of the human estrogen receptor are part of an ATP binding site.





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Copyright © 1989 by The Federation of American Societies for Experimental Biology.