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The FASEB Journal, Vol 3, 1968-1971, Copyright © 1989 by The Federation of American Societies for Experimental Biology

RESEARCH COMMUNICATIONS

Phosphosugars are potent inhibitors of central nervous system inflammation

DO Willenborg, CR Parish and WB Cowden
Division of Virology and Cellular Pathology, John Curtin School of Medical Research, Australian National University, Canberra, A.C.T.

Adoptively transferred allergic encephalomyelitis can be inhibited by various phosphosugars, particularly mannose-6-phosphate. The sugar specificity suggests that inhibition may be due to depletion of lymphocyte cell-surface lysosomal enzymes, which are essential for the passage of lymphocytes across the vascular endothelium and the entry of lymphocytes into the central nervous system parenchyma.


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Molecular Mechanisms Involved in Lymphocyte Recruitment in Inflamed Brain Microvessels: Critical Roles for P-Selectin Glycoprotein Ligand-1 and Heterotrimeric Gi-Linked Receptors
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Copyright © 1989 by The Federation of American Societies for Experimental Biology.