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The FASEB Journal, Vol 3, 1807-1817, Copyright © 1989 by The Federation of American Societies for Experimental Biology
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DG Baden
Rosenstiel School of Marine and Atmospheric Science, University of Miami, Florida 33149.
Brevetoxins are lipid-soluble polyether marine toxins of unique structure and pharmacological function. Toxins are active in vivo in the nanomolar to picomolar concentration range and in vitro in isolated neuromuscular or giant axon preparations and in single-cell or subcellular model systems. Their effect is excitatory, mediated by the enhancement of cellular Na+ influx. Brevetoxins bind at site 5 on the voltage-sensitive sodium channel, a specificity shared with ciguatoxin. This site is allosterically linked to other natural toxin binding sites on the channel.
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