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The FASEB Journal, Vol 3, 1734-1740, Copyright © 1989 by The Federation of American Societies for Experimental Biology

RESEARCH COMMUNICATIONS

Studies of 5'-deiodinase activity in rats differing in hepatic lipogenic activity

MK McIntosh, CD Berdanier and AL Kates
Department of Foods and Nutrition, University of Georgia, Athens 30602.

Studies of the relationship of hepatic 5'-deiodinase activity to hepatic lipogenic capacity were conducted. Rats of the Zucker, BHE, and Sprague-Dawley strains were used. BHE and Sprague-Dawley rats were starved and refed a 65% glucose diet, whereas lean and obese Zucker rats were fed a stock diet; the rats were thus different in hepatic lipogenic capacity. After hepatic 5'-deiodinase activity was determined, we found that rats genetically predisposed to increased hepatic lipogenesis had less deiodinase activity than rats without this genetic feature. The role of the interaction between the thyroid hormones and glucocorticoid in the activity of hepatic deiodinase was also studied. Adrenalectomized (ADX) or intact BHE and Sprague-Dawley rats were injected with saline, thyroxine, or triiodothyronine and either saline or glucocorticoid. The normal Sprague-Dawley rats made predictable adjustments to their deiodinase activity when their hormonal status was manipulated, whereas the BHE rats responded as though these manipulations were corrections rather than additions or deletions.


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M. Kim and C. D. Berdanier
Nutrient–gene interactions determine mitochondrial function: effect of dietary fat
FASEB J, February 1, 1998; 12(2): 243 - 248.
[Abstract] [Full Text]


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Copyright © 1989 by The Federation of American Societies for Experimental Biology.