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The FASEB Journal, Vol 3, 1632-1636, Copyright © 1989 by The Federation of American Societies for Experimental Biology

RESEARCH COMMUNICATIONS

Marked increase of cysteine levels in many regions of the brain after administration of 2-oxothiazolidine-4-carboxylate

ME Anderson and A Meister
Department of Biochemistry, Cornell University Medical College, New York, New York 10021.

Although brain cysteine levels can be increased by administration of cysteine, treatment with this amino acid causes toxicity. L-2- Oxothiazolidine-4-carboxylate, a compound in which the thiol group is masked, is effectively transported into the mouse and rat brain. It is converted intracellularly by the action of 5-oxoprolinase into L- cysteine. Study of various regions of the rat brain (cerebellum, hypothalamus, cortex, brain stem, pons, caudate nucleus) showed that the levels of cysteine increased significantly after administration of L-2-oxothiazolidine-4-carboxylate. Glutathione levels were not increased or were only slightly increased under these conditions, reflecting the low rate of glutathione synthesis in many regions of the brain.


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