| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
The FASEB Journal, Vol 3, 2583-2592, Copyright © 1989 by The Federation of American Societies for Experimental Biology
REVIEWS |
PF Juranka, RL Zastawny and V Ling
Ontario Cancer Institute, Canada.
The study of multidrug resistance (MDR) in tumor cell lines has led to the discovery of the plasma membrane P-glycoprotein (Pgp) molecule. This protein functions as an energy-dependent pump for the efflux of diverse anticancer drugs from MDR cells. It now appears that Pgp- mediated MDR tumor cells do occur in human cancers, and that they are likely to play a role in the ultimate response of patients to chemotherapy. Chemosensitizers, compounds able to reverse the MDR phenotype, have been identified and offer the exciting possibility of improving efficacy for some nonresponsive malignancies. Surprisingly, Pgp-like molecules can be found in evolutionarily distant species among both eukaryotes and prokaryotes. As a group, these proteins form a superfamily of ATP-dependent transport proteins. This finding has broad implications and provides new insights into how living organisms use this fundamental transport system to regulate the trafficking of diverse molecules across biological membranes.
This article has been cited by other articles:
|
|
 |
|
  W. Han, L. Li, S. Qiu, Q. Lu, Q. Pan, Y. Gu, J. Luo, and X. Hu Shikonin circumvents cancer drug resistance by induction of a necroptotic death Mol. Cancer Ther., May 1, 2007; 6(5): 1641 - 1649. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Joli, N. Bouchemal, A. Laigle, B. Hartmann, and E. Hantz Solution structure of a purine rich hexaloop hairpin belonging to PGY/MDR1 mRNA and targeted by antisense oligonucleotides Nucleic Acids Res., November 6, 2006; 34(20): 5740 - 5751. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Melaine, M.-O. Lienard, I. Dorval, C. Le Goascogne, H. Lejeune, and B. Jegou Multidrug Resistance Genes and P-Glycoprotein in the Testis of the Rat, Mouse, Guinea Pig, and Human Biol Reprod, December 1, 2002; 67(6): 1699 - 1707. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Borchers, R. Boer, K. Klemm, V. Figala, T. Denzinger, W.-R. Ulrich, S. Haas, W. Ise, V. Gekeler, and M. Przybylski Characterization of the Dexniguldipine Binding Site in the Multidrug Resistance-Related Transport Protein P-Glycoprotein by Photoaffinity Labeling and Mass Spectrometry Mol. Pharmacol., June 1, 2002; 61(6): 1366 - 1376. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Luciani, A. Molinari, F. Lozupone, A. Calcabrini, L. Lugini, A. Stringaro, P. Puddu, G. Arancia, M. Cianfriglia, and S. Fais P-glycoprotein-actin association through ERM family proteins: a role in P-glycoprotein function in human cells of lymphoid origin Blood, January 15, 2002; 99(2): 641 - 648. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. E. Cardenas, M. C. Cruz, M. Del Poeta, N. Chung, J. R. Perfect, and J. Heitman Antifungal Activities of Antineoplastic Agents: Saccharomyces cerevisiae as a Model System To Study Drug Action Clin. Microbiol. Rev., October 1, 1999; 12(4): 583 - 611. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. V. Thottassery, D. Sun, G. P. Zambetti, A. Troutman, V. P. Sukhatme, E. G. Schuetz, and J. D. Schuetz Sp1 and Egr-1 Have Opposing Effects on the Regulation of the Rat Pgp2/mdr1b Gene J. Biol. Chem., January 29, 1999; 274(5): 3199 - 3206. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. A. Pasyk, X. K. Morin, P. Zeman, E. Garami, K. Galley, L. J. Huan, Y. Wang, and C. E. Bear A Conserved Region of the R Domain of Cystic Fibrosis Transmembrane Conductance Regulator Is Important in Processing and Function J. Biol. Chem., November 27, 1998; 273(48): 31759 - 31764. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R.-Y. Lin, J. C. Vera, R. S. K. Chaganti, and D. W. Golde Human Monocarboxylate Transporter 2 (MCT2) Is a High Affinity Pyruvate Transporter J. Biol. Chem., October 30, 1998; 273(44): 28959 - 28965. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Vasudevan, T. Tsuruo, and D. R. Rose Mode of Binding of Anti-P-glycoprotein Antibody MRK-16 to Its Antigen. A CRYSTALLOGRAPHIC AND MOLECULAR MODELING STUDY J. Biol. Chem., September 25, 1998; 273(39): 25413 - 25419. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Demmer, H. Thole, P. Kubesch, T. Brandt, M. Raida, R. Fislage, and B. Tummler Localization of the Iodomycin Binding Site in Hamster P-glycoprotein J. Biol. Chem., August 15, 1997; 272(33): 20913 - 20919. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. J. Hurwitz, M. Terashima, N. Mizunuma, and C. A. Slapak Vesicular Anthracycline Accumulation in Doxorubicin-Selected U-937 Cells: Participation of Lysosomes Blood, May 15, 1997; 89(10): 3745 - 3754. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. N. Furuya, J. V. Thottassery, E. G. Schuetz, M. Sharif, and J. D. Schuetz Bromocriptine Transcriptionally Activates the Multidrug Resistance Gene (pgp2/mdr1b) by a Novel Pathway J. Biol. Chem., April 25, 1997; 272(17): 11518 - 11525. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. S. Hemenway and J. Heitman Immunosuppressant Target Protein FKBP12 Is Required for P-Glycoprotein Function in Yeast J. Biol. Chem., August 2, 1996; 271(31): 18527 - 18534. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. W. Loo and D. M. Clarke Mutational Analysis of the Predicted First Transmembrane Segment of Each Homologous Half of Human P-glycoprotein Suggests That They Are Symmetrically Arranged in the Membrane J. Biol. Chem., June 28, 1996; 271(26): 15414 - 15419. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Nare, G. Lubega, R. K. Prichard, and E. Georges p-Azidosalicyl-5-amino-6-phenoxybenzimidazole Photolabels the N-terminal 63-103 Amino Acids of Haemonchus contortus beta-Tubulin 1 J. Biol. Chem., April 12, 1996; 271(15): 8575 - 8581. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. E. Metherall, H. Li, and K. Waugh Role of Multidrug Resistance P-glycoproteins in Cholesterol Biosynthesis J. Biol. Chem., February 2, 1996; 271(5): 2634 - 2640. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. W. Loo and D. M. Clarke Covalent Modification of Human P-glycoprotein Mutants Containing a Single Cysteine in Either Nucleotide-binding Fold Abolishes Drug-stimulated ATPase Activity J. Biol. Chem., September 29, 1995; 270(39): 22957 - 22961. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Saxena and G. B. Henderson ATP-dependent Efflux of 2,4-Dinitrophenyl-S-glutathione J. Biol. Chem., March 10, 1995; 270(10): 5312 - 5319. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-T. Zhang, C. H. Lee, M. Duthie, and V. Ling Topological Determinants of Internal Transmembrane Segments in P-glycoprotein Sequences J. Biol. Chem., January 27, 1995; 270(4): 1742 - 1746. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. W. Loo and D. M. Clarke Membrane Topology of a Cysteine-less Mutant of Human P-glycoprotein J. Biol. Chem., January 13, 1995; 270(2): 843 - 848. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Monaco, S Cho, and M Attaya Transport protein genes in the murine MHC: possible implications for antigen processing Science, December 21, 1990; 250(4988): 1723 - 1726. [Abstract] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
