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The FASEB Journal, Vol 3, 2335-2343, Copyright © 1989 by The Federation of American Societies for Experimental Biology

REVIEWS

Neutralization of small RNA viruses by antibodies and antiviral agents

MG Rossmann
Department of Biological Sciences, Purdue University, West Lafayette, Indiana 47907.

The 3-dimensional structures of a number of small animal RNA viruses are now known to near-atomic resolution. All these viruses have similar structures and have, in all probability, diverged from a common ancestral virus able to infect a variety of organisms. The structures have elucidated the site of attachment to host cell receptors and the mode of protection of this site against host immune pressure. An internal hydrophobic pocket in rhinoviruses is the site for binding of antiviral drugs that inhibit uncoating and can inhibit attachment in some viruses. The pocket is probably a functional necessity, and thus is a suitable target for well-designed antiviral agents in many viruses.




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Copyright © 1989 by The Federation of American Societies for Experimental Biology.