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The FASEB Journal, Vol 3, 2189-2193, Copyright © 1989 by The Federation of American Societies for Experimental Biology

RESEARCH COMMUNICATIONS

Beneficial effects of anti-growth hormone antiserum in avian muscular dystrophy

E Kurtenbach, SS Moraes, MT Trocado, GF Lobo, PS Nascimento and S Verjovski- Almeida
Departamento de Bioquimica, Universidade Federal do Rio de Janeiro, Brazil.

Human subjects and mice have been found to have a milder progression of muscular dystrophy when the disease is associated with genotypically determined dwarfism. In this paper we describe an experimental test for reducing growth hormone in dystrophic chickens that uses rabbit anti- chicken growth hormone anti-serum (anti-cGH). Antiserum was injected daily into dystrophic (line 413) male chickens from day 1 to day 8 after hatching. Dystrophic chickens injected with anti-cGH maintained a significantly higher score in the standardized test for righting ability (P less than 0.001-0.051) from 3 to 9 1/2 wk after hatching when compared with dystrophic controls. The observed prolongation of the functional ability of injected dystrophic animals suggests that growth hormone plays a role in potentiating the symptoms of dystrophy in chickens.




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Copyright © 1989 by The Federation of American Societies for Experimental Biology.