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The FASEB Journal, Vol 3, 2179-2183, Copyright © 1989 by The Federation of American Societies for Experimental Biology

REVIEWS

Role of glucocorticoids in the regulation of lipogenesis

CD Berdanier
Department of Foods and Nutrition, University of Georgia, Athens 30602.

Traditionally, the glucocorticoids have been viewed as catabolic hormones. However, with the present knowledge about how the glucocorticoid receptor protein functions in the stimulation of mRNA synthesis, a new view must be accepted: These steroids also have an anabolic function. They are anabolic because they stimulate the de novo synthesis of enzymes of anabolic pathways. In the liver, stimulation of lipogenic enzymes has been shown. These findings suggest that glucocorticoids can increase feed efficiency and thereby play a role in the etiology of obesity.


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Copyright © 1989 by The Federation of American Societies for Experimental Biology.