The FASEB Journal, Vol 3, 2132-2140, Copyright © 1989 by The Federation of American Societies for Experimental Biology

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Plasticity of neuronal receptors

WL Klein, J Sullivan, A Skorupa and JS Aguilar
Department of Neurobiology and Physiology, Northwestern University Institute for Neuroscience, Evanston, Illinois 60208.

This article describes ways in which receptors, key components of signal propagation through a synapse, can mediate changes in that propagation. Changes occur at four levels: in the signal-transducing capability of a single receptor molecule, in the number of receptors per cell, in the subcellular placement of receptor molecules, and in the cytoarchitecture of receptor-rich regions. The ability of receptors to shift between different desired states is called plasticity, and such shifts can be long-lived as well as transient. In this article we focus on neuronal receptors, although key findings from a variety of cell systems are reported. Neuronal receptor plasticity may have a special role in the assembly as well as the adaptability of the nervous system.

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