HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Buy All Versions of this Article: fj.08-111005v1 23/6/1625    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Guicciardi, M. E. Articles by Gores, G. J. Search for Related Content PubMed PubMed Citation Articles by Guicciardi, M. E. Articles by Gores, G. J.

Life and death by death receptors

Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, Minnesota, USA

¹Correspondence: College of Medicine, Mayo Clinic, 200 First St. SW, Rochester, MN 55905, USA. E-mail: gores.gregory{at}mayo.edu

Death receptors are members of the tumor necrosis factor receptor superfamily characterized by a cytoplasmic region known as the "death domain" that enables the receptors to initiate cytotoxic signals when engaged by cognate ligands. Binding to the ligand results in receptor aggregation and recruitment of adaptor proteins, which, in turn, initiates a proteolytic cascade by recruiting and activating initiator caspases 8 and 10. Death receptors were once thought to primarily induce cytotoxic signaling cascades. However, recent data indicate that they initiate multiple signaling pathways, unveiling a number of nonapoptosis-related functions, including regulation of cell proliferation and differentiation, chemokine production, inflammatory responses, and tumor-promoting activities. These noncytotoxic cascades are not simply a manifestation of inhibiting proapoptotic pathways but are intrinsically regulated by adaptor protein and receptor internalization processes. Insights into these various death receptor signaling pathways provide new therapeutic strategies targeting these receptors in pathophysiological processes.—Guicciardi, M. E., Gores, G. J. Life and death by death receptors.

Key Words: Fas/CD95/APO1 • TNF • TRAIL • Bcl-2 family • caspases • MAP kinases

This article has been cited by other articles:

				N. Alkhouri, A. Gornicka, M. P. Berk, S. Thapaliya, L. J. Dixon, S. Kashyap, P. R. Schauer, and A. E. Feldstein Adipocyte Apoptosis, a Link between Obesity, Insulin Resistance, and Hepatic Steatosis J. Biol. Chem., January 29, 2010; 285(5): 3428 - 3438. [Abstract] [Full Text] [PDF]

				X. W. Meng, M. P. Heldebrant, K. S. Flatten, D. A. Loegering, H. Dai, P. A. Schneider, T. S. Gomez, K. L. Peterson, S. A. Trushin, A. D. Hess, et al. Protein Kinase C{beta} Modulates Ligand-induced Cell Surface Death Receptor Accumulation: A MECHANISTIC BASIS FOR ENZASTAURIN-DEATH LIGAND SYNERGY J. Biol. Chem., January 8, 2010; 285(2): 888 - 902. [Abstract] [Full Text] [PDF]