HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) All Versions of this Article: fj.06-6837comv1 fj.06-6837comv2 21/1/256    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Sugimoto, H. Articles by Kalluri, R. Search for Related Content PubMed PubMed Citation Articles by Sugimoto, H. Articles by Kalluri, R.

BMP-7 functions as a novel hormone to facilitate liver regeneration

Hikaru Sugimoto^*,1, Changqing Yang^*,1, Valerie S. LeBleu^*, Mary A. Soubasakos^*, Mauricio Giraldo^*, Michael Zeisberg^* and Raghu Kalluri^*,,,2

^* Division of Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachussetts, USA;

Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts, USA;

Harvard-MIT Division of Health Sciences and Technology, Boston, Massachusetts, USA

²Correspondence: Harvard Medical School, Division of Matrix Biology, Beth Israel Deaconess Medical Center, Department of Medicine, Dana 514, 330 Brookline Ave., Boston, MA 02215, USA. E-Mail: rkalluri{at}bidmc.harvard.edu

Bone morphogenic protein-7 (BMP-7) is a key protein involved in liver organogenesis and development. The physiological circulating concentration of BMP-7 is between 100 and 300 pg/ml. BMP-7 expression is absent in the liver, but the receptors for BMP-7 are present on adult hepatocytes. Therefore, we hypothesized that BMP-7 might function as an endogenous regulator of adult hepatocyte proliferation and liver homeostasis. Here, we demonstrate that neutralization of circulating endogenous BMP-7 results in significantly impaired regeneration of the liver after partial hepatectomy. Therapeutic administration of recombinant human BMP-7 (rhBMP-7) significantly enhances liver regeneration associated with accelerated improvement of liver function. Collectively, our results argue for the role of BMP-7 as a kidney- and bone-produced endogenous regulator of hepatocyte health.—Sugimoto, H., Yang, C., LeBleu, V. S., Soubasakos, M. A., Giraldo, M., Zeisberg, M., Kalluri, R. BMP-7 functions as a novel hormone to facilitate liver regeneration.

Key Words: transforming growth factor ß • hepatocytes

This article has been cited by other articles:

				L. David, C. Mallet, M. Keramidas, N. Lamande, J.-M. Gasc, S. Dupuis-Girod, H. Plauchu, J.-J. Feige, and S. Bailly Bone Morphogenetic Protein-9 Is a Circulating Vascular Quiescence Factor Circ. Res., April 25, 2008; 102(8): 914 - 922. [Abstract] [Full Text] [PDF]

				G. M. Mitu, S. Wang, and R. Hirschberg BMP7 is a podocyte survival factor and rescues podocytes from diabetic injury Am J Physiol Renal Physiol, November 1, 2007; 293(5): F1641 - F1648. [Abstract] [Full Text] [PDF]

				M. Zeisberg, C. Yang, M. Martino, M. B. Duncan, F. Rieder, H. Tanjore, and R. Kalluri Fibroblasts Derive from Hepatocytes in Liver Fibrosis via Epithelial to Mesenchymal Transition J. Biol. Chem., August 10, 2007; 282(32): 23337 - 23347. [Abstract] [Full Text] [PDF]