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The Departments of Cell Biology and Pediatrics and the Medical Scientist Training Program at the University of Alabama at Birmingham, Birmingham, Alabama, USA
1Correspondence: Department of Pediatrics & Cell Biology, The University of Alabama at Birmingham, VH 648A, 1670 University Blvd., Birmingham, AL 35294-0019, USA. E-mail: jhagood{at}peds.uab.edu
Thy-1 (CD90) is a 25–37 kDa glycosylphosphatidylinositol (GPI) -anchored glycoprotein expressed on many cell types, including T cells, thymocytes, neurons, endothelial cells, and fibroblasts. Activation of Thy-1 can promote T cell activation, and this role of Thy-1 is reviewed elsewhere. Thy-1 also affects numerous nonimmunologic biological processes, including cellular adhesion, neurite outgrowth, tumor growth, migration, and cell death. In reviewing the nonimmunologic functions of Thy-1, we discuss the phenotype of the Thy-1 null mouse, signaling pathways modulated by Thy-1, the role of the GPI anchor in Thy-1 localization to lipid rafts and signaling, and regulation of Thy-1 expression. Thy-1 is an important regulator of cell-cell and cell-matrix interactions, with important roles in nerve regeneration, metastasis, inflammation, and fibrosis.—Rege, T. A., Hagood, J. S. Thy-1 as a regulator of cell-cell and cell-matrix interactions in axon regeneration, apoptosis, adhesion, migration, cancer, and fibrosis.
Key Words: neurite outgrowth • tumor suppressor • GPI anchor • wound healing
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