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Thy-1 as a regulator of cell-cell and cell-matrix interactions in axon regeneration, apoptosis, adhesion, migration, cancer, and fibrosis

The Departments of Cell Biology and Pediatrics and the Medical Scientist Training Program at the University of Alabama at Birmingham, Birmingham, Alabama, USA

¹Correspondence: Department of Pediatrics & Cell Biology, The University of Alabama at Birmingham, VH 648A, 1670 University Blvd., Birmingham, AL 35294-0019, USA. E-mail: jhagood{at}peds.uab.edu

Thy-1 (CD90) is a 25–37 kDa glycosylphosphatidylinositol (GPI) -anchored glycoprotein expressed on many cell types, including T cells, thymocytes, neurons, endothelial cells, and fibroblasts. Activation of Thy-1 can promote T cell activation, and this role of Thy-1 is reviewed elsewhere. Thy-1 also affects numerous nonimmunologic biological processes, including cellular adhesion, neurite outgrowth, tumor growth, migration, and cell death. In reviewing the nonimmunologic functions of Thy-1, we discuss the phenotype of the Thy-1 null mouse, signaling pathways modulated by Thy-1, the role of the GPI anchor in Thy-1 localization to lipid rafts and signaling, and regulation of Thy-1 expression. Thy-1 is an important regulator of cell-cell and cell-matrix interactions, with important roles in nerve regeneration, metastasis, inflammation, and fibrosis.—Rege, T. A., Hagood, J. S. Thy-1 as a regulator of cell-cell and cell-matrix interactions in axon regeneration, apoptosis, adhesion, migration, cancer, and fibrosis.

Key Words: neurite outgrowth • tumor suppressor • GPI anchor • wound healing

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