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New surprises in genetic coding and how an ingenious experiment was almost scooped, by evolution

Department of Biochemistry and Molecular Pharmacology, Program in Cell Dynamics, University of Massachusetts Medical School, Worcester, Massachusetts, USA

²Department of Biochemistry and Molecular Pharmacology, Program in Cell Dynamics, University of Massachusetts Medical School, 377 Plantation St., Worcester, MA 01605, USA. E-mail: thoru.pederson{at}umassmed.edu

ABSTRACT

SUMMARY In 1962, one of the most creative and cogent experiments on the protein coding problem was published. Now it has been discovered that archaebacteria had been doing a related kind of "experiment" all along. Both involve a trick: changing an amino acid that is already attached to a "correct" transfer RNA.

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