FASEB J. Cell Migration Consortium
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Broxterman, H. J.
Right arrow Articles by Lankelma, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Broxterman, H. J.
Right arrow Articles by Lankelma, J.

The FASEB Journal, Vol 2, 2278-2282, Copyright © 1988 by The Federation of American Societies for Experimental Biology

RESEARCH COMMUNICATIONS

Induction by verapamil of a rapid increase in ATP consumption in multidrug-resistant tumor cells

HJ Broxterman, HM Pinedo, CM Kuiper, LC Kaptein, GJ Schuurhuis and J Lankelma
Department of Oncology, Free University Hospital, Amsterdam, The Netherlands.

A marked increase in cellular ATP consumption was induced by verapamil in the multidrug-resistant (MDR) cell line 2780AD, but not in the drug- sensitive parental cell line A2780. A group of structurally unrelated drugs in concentrations known to reverse MDR, but not the verapamil analog tiapamil, a weak modulator of MDR, had similar effects. This effect was saturated at verapamil concentrations of about 1 microM. These data demonstrate that verapamil concentrations in MDR cells are maintained at a low level at the expense of ATP hydrolysis, and provide a first indication of the amount of metabolic energy used in this process.


This article has been cited by other articles:


Home page
 BloodHome page
R. W. Johnstone, E. Cretney, and M. J. Smyth
P-Glycoprotein Protects Leukemia Cells Against Caspase-Dependent, but not Caspase-Independent, Cell Death
Blood, February 1, 1999; 93(3): 1075 - 1085.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
G. D. Eytan, R. Regev, and Y. G. Assaraf
Functional Reconstitution of P-glycoprotein Reveals an Apparent Near Stoichiometric Drug Transport to ATP Hydrolysis
J. Biol. Chem., February 9, 1996; 271(6): 3172 - 3178.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1988 by The Federation of American Societies for Experimental Biology.