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The FASEB Journal, Vol 2, 3108-3112, Copyright © 1988 by The Federation of American Societies for Experimental Biology

RESEARCH COMMUNICATIONS

Lipogenic potential in liver of the preweanling rat: influence of dietary cholesterol

N Auestad, RA Korsak, JW Morrow, DB West, JD Bergstrom and J Edmond
Division of Nutritional Sciences, UCLA School of Public Health.

We examined the effect of a lower dietary cholesterol load on hepatic lipogenic capacity and plasma cholesterol concentrations during the normal suckling period in artificially reared preweanling rats. The artificially reared rats were fed a milk formula that contained low or normal concentrations of cholesterol during the period from the 5th to 17th day after birth. The activities of HMG-CoA synthase and HMG-CoA reductase in livers of 17-day-old rat pups reared on the low- cholesterol diet were enhanced three- to five-fold over those observed in the age-matched rats in the normal cholesterol and mother-reared control groups. The concentration of cholesterol in plasma of rats reared on the low-cholesterol milk was about 20% lower than that for mother-reared controls. In contrast, rats reared on milk with normal cholesterol content exhibited plasma cholesterol levels about 25 and 50% higher than the mother-reared and low cholesterol groups, respectively. The long-term metabolic consequences of rearing rats on milk formulations without adequate cholesterol remains to be determined.




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Copyright © 1988 by The Federation of American Societies for Experimental Biology.