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The FASEB Journal, Vol 2, 3083-3086, Copyright © 1988 by The Federation of American Societies for Experimental Biology

RESEARCH COMMUNICATIONS

In vivo glucose utilization by individual tissues during nonlethal hypermetabolic sepsis

K Meszaros, CH Lang, GJ Bagby and JJ Spitzer
Department of Physiology, Louisiana State University Medical Center, New Orleans 70112.

Febrile sepsis was induced in rats by repeated s.c. injections of live Escherichia coli bacteria. Glucose utilization of different tissues was investigated in vivo by using the 2-deoxyglucose tracer technique. In septic rats the rate of glucose utilization was increased in macrophage- rich tissues, including the liver (2.7-fold), spleen (2.4-fold), and ileum (1.6-fold), compared with tissues from time-matched nonseptic animals. A smaller increase in glucose utilization was evident in the abdominal muscle (1.3-fold) and in the white portion of the quadriceps muscle (1.3-fold). Changes were not significant in nine other tissues, including the brain. We postulate that in sepsis the mononuclear phagocyte system may be responsible for most of the increment of glucose utilization, and the latter provides metabolic support for the increased antibacterial activity of these cells.


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Copyright © 1988 by The Federation of American Societies for Experimental Biology.