FASEB J. Cell Migration Consortium
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Ogata, N.
Right arrow Articles by Narahashi, T.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ogata, N.
Right arrow Articles by Narahashi, T.

The FASEB Journal, Vol 2, 2895-2900, Copyright © 1988 by The Federation of American Societies for Experimental Biology

RESEARCH COMMUNICATIONS

Lindane but not deltamethrin blocks a component of GABA-activated chloride channels

N Ogata, SM Vogel and T Narahashi
Department of Pharmacology, Northwestern University Medical School, Chicago, Illinois 60611.

Effects of deltamethrin, a pyrethroid insecticide, and lindane, the gamma isomer of hexachlorocyclohexane, on the gamma-aminobutyric acid (GABA)-activated ion channels were studied using cultured neurons isolated from the newborn rat dorsal root ganglia. The neuron was voltage clamped using the whole cell patch clamp technique. Two components of inward chloride currents were generated in response to bath application of GABA. One of the components was selectively blocked by 1 x 10(-5)M lindane in a stereospecific manner, but neither component was affected by 1 x 10(-5)M deltamethrin, which drastically prolonged the voltage-activated sodium channel current. Thus, the action of lindane to stimulate the nervous system is partly because of an interaction with the GABA receptor-channel complex. The target site of deltamethrin is not the GABA receptor-channel complex but the sodium channel. The results suggest a multiplicity of the GABAA receptor- chloride channel complex.


This article has been cited by other articles:


Home page
 Toxicol SciHome page
M. J. Wolansky, C. Gennings, and K. M. Crofton
Relative Potencies for Acute Effects of Pyrethroids on Motor Function in Rats
Toxicol. Sci., January 1, 2006; 89(1): 271 - 277.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
T. Narahashi
Neuroreceptors and Ion Channels as the Basis for Drug Action: Past, Present, and Future
J. Pharmacol. Exp. Ther., July 1, 2000; 294(1): 1 - 26.
[Abstract] [Full Text]

Home page
 J. Neurosci.Home page
J. Liu, A. L. Morrow, L. Devaud, D. R. Grayson, and J. M. Lauder
GABAA Receptors Mediate Trophic Effects of GABA on Embryonic Brainstem Monoamine Neurons In Vitro
J. Neurosci., April 1, 1997; 17(7): 2420 - 2428.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
K. M. Hold, N. S. Sirisoma, T. Ikeda, T. Narahashi, and J. E. Casida
alpha -Thujone (the active component of absinthe): gamma -Aminobutyric acid type A receptor modulation and metabolic detoxification
PNAS, April 11, 2000; 97(8): 3826 - 3831.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1988 by The Federation of American Societies for Experimental Biology.