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The FASEB Journal, Vol 2, 2878-2883, Copyright © 1988 by The Federation of American Societies for Experimental Biology

RESEARCH COMMUNICATIONS

In vitro cytocidal effect of novel lytic peptides on Plasmodium falciparum and Trypanosoma cruzi

JM Jaynes, CA Burton, SB Barr, GW Jeffers, GR Julian, KL White, FM Enright, TR Klei and RA Laine
Department of Biochemistry, Louisiana State University, Baton Rouge 70803.

Plasmodium falciparum and Trypanosoma cruzi were killed by two novel lytic peptides (SB-37 and Shiva-1) in vitro. Human erythrocytes infected with P. falciparum, and Vero cells infected with T. cruzi, were exposed to these peptides. The result, in both cases, was a significant decrease in the level of parasite infection. Furthermore, the peptides had a marked cytocidal effect on trypomastigote stages of T. cruzi in media, whereas host eukaryotic cells were unaffected by the treatments. In view of the worldwide prevalence of these protozoan diseases and the lack of completely suitable treatments, lytic peptides may provide new and unique chemotherapeutic agents for the treatment of these infections.


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Copyright © 1988 by The Federation of American Societies for Experimental Biology.