FASEB J.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Weiss, E. R.
Right arrow Articles by Johnson, G. L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Weiss, E. R.
Right arrow Articles by Johnson, G. L.

The FASEB Journal, Vol 2, 2841-2848, Copyright © 1988 by The Federation of American Societies for Experimental Biology

REVIEWS

Receptor activation of G proteins

ER Weiss, DJ Kelleher, CW Woon, S Soparkar, S Osawa, LE Heasley and GL Johnson
Department of Biochemistry, University of Massachusetts Medical School, Worcester 01655.

G proteins are a highly conserved family of membrane-associated proteins composed of alpha, beta, and gamma subunits. The alpha subunit, which is unique for each G protein, binds GDP or GTP. Receptors such as those for beta- and alpha-adrenergic catecholamines, muscarinic agonists, and the retinal photoreceptor rhodopsin, catalyze the exchange of GDP for GTP binding to the alpha subunit of a specific G protein. G alpha.GTP regulates appropriate effector enzymes such as adenylyl cyclase or the cyclic GMP phosphodiesterase. The beta gamma- subunit complex of G proteins is required for efficient receptor- catalyzed alpha subunit guanine nucleotide exchange and also functions as an attenuator of alpha subunit activation of effector enzymes. Recent elucidation of both receptor and G protein primary sequence has allowed structural predictions and new experimental approaches to study the mechanism of receptor-catalyzed G protein regulation of specific effector systems and the control of cell function including metabolism, secretion, and growth.


This article has been cited by other articles:


Home page
 J. Biol. Chem.Home page
A. Terakita, T. Yamashita, N. Nimbari, D. Kojima, and Y. Shichida
Functional Interaction between Bovine Rhodopsin and G Protein Transducin
J. Biol. Chem., January 4, 2002; 277(1): 40 - 46.
[Abstract] [Full Text]

Home page
 J. Biol. Chem.Home page
A. Ben-Baruch, K. M. Bengali, A. Biragyn, J. J. Johnston, J.-M. Wang, J. Kim, A. Chuntharapai, D. F. Michiel, J. J. Oppenheim, and D. J. Kelvin
Interleukin-8 Receptor [IMAGE]
J. Biol. Chem., April 21, 1995; 270(16): 9121 - 9128.
[Abstract] [Full Text] [PDF]

Home page
 J Biol RhythmsHome page
W. S. Warren, D. B. Hodges, and V. M. Cassone
Pinealectomized Rats Entrain and Phase-Shift to Melatonin Injections in a Dose-Dependent Manner
J Biol Rhythms, October 1, 1993; 8(3): 233 - 245.
[Abstract] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1988 by The Federation of American Societies for Experimental Biology.